Palmitoleic and oleic fatty acids as biomarkers for coronary heart disease: A predictive model.

IF 1.7 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Irish Journal of Medical Science Pub Date : 2024-11-08 DOI:10.1007/s11845-024-03839-7

Guangzhou Wang, Lin Zhou, Zhengfang Wang, Asmaa Ali, Liang Wu

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引用次数: 0

Abstract

Background: saturated and unsaturated fatty acid showed a significant link with coronary artery health and disease.

Objective: This study aimed to compare plasma levels of unsaturated fatty acids (UFAs) between individuals with coronary heart disease (CHD) and those without. It also investigated the association between specific UFA ratios and the presence or severity of acute coronary syndrome (ACS). Additionally, the study explored the potential of UFAs as biomarkers for assessing CHD risk or disease severity.

Method: Patients suspected of coronary heart disease (CHD) at Northern Jiangsu People's Hospital were categorized by coronary angiography into non-CHD (53 cases) and CHD (182 cases). The CHD group was divided into non-acute coronary syndrome (non-ACS) (40 cases) and ACS (142 cases) subgroups. The ACS group was further classified into unstable angina (61 cases), non-ST-elevation myocardial infarction (NSTEMI) (40 cases), and ST-elevation myocardial infarction (STEMI) (41 cases). Lipid profiles, myocardial injury markers, and fourteen unsaturated fatty acids were analyzed using liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS).

Results: The CHD group had significantly higher triglycerides (TG), palmitoleic acid (PA), oleic acid (OA), docosahexaenoic acid (DHA), ω-6 fatty acids, and a higher ω-6/ω-3 ratio, but lower ω-3 fatty acids compared to non-CHD. In ACS, PA, LA, OA, and the ω-6/ω-3 ratio were elevated, while EPA and HDL were reduced. Logistic regression identified TG, ω-6/ω-3 ratio, PA, OA, and ω-6 fatty acids as risk factors, with ω-3 fatty acids being protective. PA was protective, while OA posed risk. A combined PA and OA model had a diagnostic efficacy (AUC 0.746).

Conclusion: Altered fatty acid metabolism in CHD patients, particularly PA and OA, offers potential as biomarkers. The ω-6/ω-3 ratio is crucial for cardiovascular health.

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棕榈油酸和油酸脂肪酸作为冠心病的生物标志物：预测模型

背景：饱和脂肪酸和不饱和脂肪酸与冠状动脉健康和疾病有重要关系：本研究旨在比较冠心病（CHD）患者和非冠心病患者血浆中的不饱和脂肪酸（UFAs）水平。研究还调查了特定的不饱和脂肪酸比率与急性冠状动脉综合征（ACS）的存在或严重程度之间的关联。此外，该研究还探讨了将 UFAs 作为生物标志物用于评估冠心病风险或疾病严重程度的潜力：方法：苏北人民医院通过冠状动脉造影将疑似冠心病（CHD）患者分为非CHD组（53例）和CHD组（182例）。冠心病组又分为非急性冠状动脉综合征（非 ACS）（40 例）和 ACS（142 例）亚组。ACS 组又分为不稳定型心绞痛（61 例）、非 ST 段抬高型心肌梗死（NSTEMI）（40 例）和 ST 段抬高型心肌梗死（STEMI）（41 例）。采用液相色谱-质谱/质谱联用技术（LC-MS/MS）分析了血脂概况、心肌损伤标志物和十四种不饱和脂肪酸：结果：与非心脏病组相比，心脏病组的甘油三酯（TG）、棕榈油酸（PA）、油酸（OA）、二十二碳六烯酸（DHA）、ω-6脂肪酸含量明显较高，ω-6/ω-3比率也较高，但ω-3脂肪酸含量较低。在 ACS 中，PA、LA、OA 和 ω-6/ω-3 比值升高，而 EPA 和 HDL 降低。逻辑回归确定总胆固醇、ω-6/ω-3 比率、PA、OA 和ω-6 脂肪酸为风险因素，而ω-3 脂肪酸具有保护作用。PA 具有保护作用，而 OA 则具有风险。综合 PA 和 OA 模型具有诊断功效（AUC 0.746）：结论：冠心病患者脂肪酸代谢的改变，尤其是 PA 和 OA，具有作为生物标志物的潜力。ω-6/ω-3比率对心血管健康至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Irish Journal of Medical Science 医学-医学：内科

CiteScore

3.70

自引率

4.80%

发文量

357

审稿时长

4-8 weeks

期刊介绍： The Irish Journal of Medical Science is the official organ of the Royal Academy of Medicine in Ireland. Established in 1832, this quarterly journal is a contribution to medical science and an ideal forum for the younger medical/scientific professional to enter world literature and an ideal launching platform now, as in the past, for many a young research worker. The primary role of both the Academy and IJMS is that of providing a forum for the exchange of scientific information and to promote academic discussion, so essential to scientific progress.