Acute cholangitis caused by coinfection with zoonotic pathogens of Gallibacterium anatis and Enterococcus cecorum: A case report

IF 4.8 2区医学 Q1 INFECTIOUS DISEASES

International Journal of Infectious Diseases Pub Date : 2024-11-06 DOI:10.1016/j.ijid.2024.107292

Masahiro Kodana , Kazuo Imai , Tetsuyoshi Takayama , Masaomi Suzuki , Toru Kawamura , Ryuha Omachi , Hiroshi Asano , Takuya Maeda

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引用次数: 0

Abstract

Background

Gallibacterium anatis and Enterococcus cecorum are considered to be emerging infectious pathogens in poultry, particularly in the European Union. These bacteria are isolated on rare occasions from immunocompromised hosts and cause opportunistic infections associated with the ingestion of contaminated food. Here, we report the first case of G. anatis and E. cecorum coinfection in an immunocompetent host and clarify the genomic characteristics of these bacteria.

Case presentation

A 78-year-old Japanese man diagnosed with acute cholangitis as a result of a common bile duct stone was hospitalized in 2021. He was treated with endoscopic papillary large-balloon dilation and antibiotics. His blood culture was positive for G. anatis and E. cecorum. Whole-genome sequencing identified that our isolate of G. anatis belongs to a highly virulent biovar haemolytica strain and our isolate of E. cecorum had multidrug resistance genes, which have commonly been found in U.S. strains.

Conclusion

A common bile duct stone that impairs bile flow is a risk factor for G. anatis and E. cecorum infection in an immunocompetent host. This report indicates the need for further surveillance of G. anatis and E. cecorum in animals as well as for investigation of their pathogenesis in humans.

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人畜共患病原体安氏加里布氏菌和盲肠球菌合并感染引起的急性胆管炎：病例报告。

背景：解剖型加利杆菌和盲肠球菌被认为是家禽中新出现的传染性病原体，尤其是在欧盟。这些细菌极少从免疫力低下的宿主体内分离出来，并因摄入受污染的食物而引起机会性感染。在此，我们报告了首例在免疫功能健全的宿主中发生的锐疽疽杆菌和盲肠球菌合并感染病例，并阐明了这些细菌的基因组特征：一名 78 岁的日本男性因胆总管结石导致急性胆管炎于 2021 年住院治疗。他接受了内镜下乳头状大气囊扩张术和抗生素治疗。他的血液培养结果显示锐疽疽杆菌和盲肠球菌呈阳性。全基因组测序结果表明，我们分离到的G. anatis属于高致病性生物菌株，而我们分离到的E. cecorum则具有多药耐药基因，这在美国菌株中很常见：结论：影响胆汁流动的胆总管结石是免疫功能正常的宿主感染 G. anatis 和 E. cecorum 的危险因素。本报告表明，有必要进一步监测动物中的锐疽葡萄球菌和盲肠球虫，并调查它们在人类中的致病机理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Infectious Diseases 医学-传染病学

CiteScore

18.90

自引率

2.40%

发文量

1020

审稿时长

30 days

期刊介绍： International Journal of Infectious Diseases (IJID) Publisher: International Society for Infectious Diseases Publication Frequency: Monthly Type: Peer-reviewed, Open Access Scope: Publishes original clinical and laboratory-based research. Reports clinical trials, reviews, and some case reports. Focuses on epidemiology, clinical diagnosis, treatment, and control of infectious diseases. Emphasizes diseases common in under-resourced countries.