Early Enteral Feeding Restores Neurofilament Light Chain Serum Levels in Preterm Newborns.

IF 4.8 2区 医学 Q1 NEUROSCIENCES
Maria Di Chiara, Gianluca Terrin, Marco Fiore, Maria Chiara De Nardo, Gianluigi Laccetta, Flavia Gloria, Antonio Minni, Christian Barbato, Carla Petrella
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Abstract

Background: Positive effects of early nutritional strategies on neurological outcomes have been observed when nutrients were administered by the enteral route, especially during the first week of life. Evidence reports that serum neurofilament light chain (NfL), a structural protein of neurons, is a specific and reliable biomarker of neuronal damage.

Objective: The present study aimed to investigate the effect of early enteral nutrition (EN) in minimizing neuroaxonal damage and assessing NfL serum levels in preterm neonates.

Methods: Fifty-four preterm neonates without severe brain impairment and 20 full-term babies as controls were enrolled from the Neonatal Intensive Care Unit at the Policlinico Umberto I in Rome. We performed blood sampling at birth (day of life 0 - DoL 0) in 20 full-term newborns and in 19 pre-term infants. Furthermore, we executed blood sampling at DoL 28 in other 22 pre-term newborns who received early enteral nutrition (EN) within the third DoL (Early-EN) and in 13 other pre-term newborns who received EN after the third DoL (Late-EN).

Results: Serum levels of NfL were higher in preterm babies when compared to full-term neonates, at DoL 0 (48.81 ± 9.4 vs. 11.67 ± 1.4 pg/ml; p = 0.007). Interestingly, at DoL 28, serum NfL was significantly decreased in the Early-EN newborns compared to the Late-EN groups (15.22 ± 2.0 vs. 50.05 ± 17.9 pg/ml; p = 0.03).

Conclusions: It was shown that early enteral feeding, within the first week of life, could be a useful tool for limiting neurological impairment in pre-term neonates by restoring NfL.

早期肠内喂养可恢复早产新生儿的神经丝轻链血清水平
背景:早期营养策略对神经系统预后的积极影响已在通过肠道途径给予营养物质时被观察到,尤其是在婴儿出生后的第一周。有证据表明,血清神经丝轻链(NfL)是神经元的一种结构蛋白,是神经元损伤的一种特异而可靠的生物标志物:本研究旨在探讨早期肠内营养(EN)对减少早产新生儿神经轴突损伤和评估NfL血清水平的影响:罗马翁贝托一世医院(Policlinico Umberto I)新生儿重症监护室招募了54名无严重脑损伤的早产新生儿和20名足月儿作为对照。我们对 20 名足月新生儿和 19 名早产儿进行了出生时(生命第 0 天)的血液采样。此外,我们还在出生后第 28 天对另外 22 名在出生后第 3 天内接受早期肠内营养(EN)的早产新生儿(Early-EN)和另外 13 名在出生后第 3 天后接受 EN 的早产新生儿(Late-EN)进行了血液采样:结果:与足月新生儿相比,早产儿在DoL 0时的血清NfL水平更高(48.81 ± 9.4 vs. 11.67 ± 1.4 pg/ml;p = 0.007)。有趣的是,与晚期新生儿组相比,早期新生儿组的血清 NfL 在 DoL 28 时明显下降(15.22 ± 2.0 vs. 50.05 ± 17.9 pg/ml;p = 0.03):研究表明,在新生儿出生后第一周内进行早期肠内喂养可通过恢复 NfL 来限制早产新生儿的神经功能损伤。
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来源期刊
Current Neuropharmacology
Current Neuropharmacology 医学-神经科学
CiteScore
8.70
自引率
1.90%
发文量
369
审稿时长
>12 weeks
期刊介绍: Current Neuropharmacology aims to provide current, comprehensive/mini reviews and guest edited issues of all areas of neuropharmacology and related matters of neuroscience. The reviews cover the fields of molecular, cellular, and systems/behavioural aspects of neuropharmacology and neuroscience. The journal serves as a comprehensive, multidisciplinary expert forum for neuropharmacologists and neuroscientists.
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