Stimuli-Responsive Nano/Biomaterials for Smart Drug Delivery in Cardiovascular Diseases: Promises, Challenges and Outlooks.

IF 3.5 4区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current medicinal chemistry Pub Date : 2024-11-07 DOI:10.2174/0109298673319981241021063524

Pegah Vosoughi, Seyed Morteza Naghib, M R Mozafari

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Abstract

Cardiovascular Diseases (CVDs) are responsible for the highest number of deaths and disabilities globally. Although numerous therapeutic options exist for treating CVDs, most traditional strategies have proven ineffective in halting or significantly slowing disease progression, often leading to unfavorable side effects. Using nanocarriers represents an innovative strategy for treating CVD, enabling the personalized delivery of medications to precise locations within the cardiovascular system. Despite significant advancements in pharmacological treatments, challenges persist in effectively administering drugs to the CV system. Employing nanocarriers represents an innovative strategy for treating CVD, enabling the tailored administration of medications to precise locations within the cardiovascular system. Various studies have determined the future outlook of nanomedicines for clinical applications as nanocarrier design continues to improve, leading to enhanced drug delivery and treatment outcomes. The article focuses on the delivery systems of drugs that are effective strategies for treating cardiovascular diseases. This manuscript also seeks to explore new possibilities for how the emerging concept of nanotherapeutics could revolutionize our traditional diagnostic and treatment methods in the coming years.

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用于心血管疾病智能给药的刺激响应型纳米/生物材料：前景、挑战和展望。

心血管疾病（CVDs）是全球致死和致残人数最多的疾病。虽然治疗心血管疾病的方法有很多，但事实证明，大多数传统方法都无法有效阻止或显著减缓疾病的发展，而且往往会产生不良副作用。使用纳米载体是治疗心血管疾病的一种创新策略，可将药物个性化地输送到心血管系统内的精确位置。尽管在药物治疗方面取得了重大进展，但在心血管系统有效给药方面仍然存在挑战。采用纳米载体是治疗心血管疾病的一种创新策略，可将药物量身定制地输送到心血管系统的精确位置。随着纳米载体设计的不断改进，各种研究确定了纳米药物临床应用的未来前景，从而提高了药物输送和治疗效果。本文重点介绍了治疗心血管疾病的有效策略--药物输送系统。本稿件还试图探讨新兴的纳米治疗概念如何在未来几年彻底改变我们传统的诊断和治疗方法的新可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current medicinal chemistry 医学-生化与分子生物学

CiteScore

8.60

自引率

2.40%

发文量

468

审稿时长

3 months

期刊介绍： Aims & Scope Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.