The function of nicotinamide phosphoribosyl transferase (NAMPT) and its role in diseases.

IF 3.9 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Frontiers in Molecular Biosciences Pub Date : 2024-10-24 eCollection Date: 2024-01-01 DOI:10.3389/fmolb.2024.1480617

Aihong Peng, Junqin Li, Jianxiao Xing, Yuanjun Yao, Xuping Niu, Kaiming Zhang

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Abstract

Nicotinamide phosphoribosyl transferase (NAMPT) is a rate-limiting enzyme in the mammalian nicotinamide adenine dinucleotide (NAD) salvage pathway, and plays a vital role in the regulation of cell metabolic activity, reprogramming, aging and apoptosis. NAMPT synthesizes nicotinamide mononucleotide (NMN) through enzymatic action, which is a key protein involved in host defense mechanism and plays an important role in metabolic homeostasis and cell survival. NAMPT is involved in NAD metabolism and maintains intracellular NAD levels. Sirtuins (SIRTs) are a family of nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylases (HDACs), the members are capable of sensing cellular NAD+ levels. NAMPT-NAD and SIRT constitute a powerful anti-stress defense system. In this paper, the structure, biological function and correlation with diseases of NAMPT are introduced, aiming to provide new ideas for the targeted therapy of related diseases.

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烟酰胺磷酸核糖转移酶（NAMPT）的功能及其在疾病中的作用。

烟酰胺磷酸核糖转移酶（NAMPT）是哺乳动物烟酰胺腺嘌呤二核苷酸（NAD）挽救途径中的限速酶，在调控细胞代谢活动、重编程、衰老和凋亡中发挥着重要作用。NAMPT 通过酶促作用合成烟酰胺单核苷酸（NMN），NMN 是参与宿主防御机制的关键蛋白，在代谢平衡和细胞存活中发挥重要作用。NAMPT 参与 NAD 代谢，维持细胞内 NAD 水平。Sirtuins（SIRTs）是一个依赖于烟酰胺腺嘌呤二核苷酸（NAD）的组蛋白去乙酰化酶（HDACs）家族，其成员能够感知细胞内的 NAD+ 水平。NAMPT-NAD 和 SIRT 构成了一个强大的抗应激防御系统。本文介绍了NAMPT的结构、生物学功能以及与疾病的相关性，旨在为相关疾病的靶向治疗提供新思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Molecular Biosciences Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

7.20

自引率

4.00%

发文量

1361

审稿时长

14 weeks

期刊介绍： Much of contemporary investigation in the life sciences is devoted to the molecular-scale understanding of the relationships between genes and the environment — in particular, dynamic alterations in the levels, modifications, and interactions of cellular effectors, including proteins. Frontiers in Molecular Biosciences offers an international publication platform for basic as well as applied research; we encourage contributions spanning both established and emerging areas of biology. To this end, the journal draws from empirical disciplines such as structural biology, enzymology, biochemistry, and biophysics, capitalizing as well on the technological advancements that have enabled metabolomics and proteomics measurements in massively parallel throughput, and the development of robust and innovative computational biology strategies. We also recognize influences from medicine and technology, welcoming studies in molecular genetics, molecular diagnostics and therapeutics, and nanotechnology. Our ultimate objective is the comprehensive illustration of the molecular mechanisms regulating proteins, nucleic acids, carbohydrates, lipids, and small metabolites in organisms across all branches of life. In addition to interesting new findings, techniques, and applications, Frontiers in Molecular Biosciences will consider new testable hypotheses to inspire different perspectives and stimulate scientific dialogue. The integration of in silico, in vitro, and in vivo approaches will benefit endeavors across all domains of the life sciences.