A nonlinear relationship between dietary inflammatory index and stroke among US adults with metabolic dysfunction-associated steatotic liver disease.

IF 2.3 4区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

European Journal of Gastroenterology & Hepatology Pub Date : 2025-03-01 Epub Date: 2024-10-31 DOI:10.1097/MEG.0000000000002876

Renwei Guo, Juan Du

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引用次数: 0

Abstract

Background: Some studies have found that high dietary inflammatory index (DII) increases stroke risk, but previous studies have mostly been conducted in the general population, and the exact relationship between DII and stroke in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) is not clear.

Methods: This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (2009-2016) to investigate the association between the DII and stroke. DII was computed according to established methods. Participants were categorized into tertiles of DII (Q1-Q3). Multivariate weighted logistic regression analysis, smooth curve fitting, and subgroup analysis were employed to explore this relationship. Subgroup analyses were conducted based on demographic and clinical variables.

Results: A total of 2426 individuals were enrolled in our study. The overall prevalence of stroke in the study population was 4.66%. The smooth curve fitting analysis indicated a J-shaped relationship between DII and stroke among individuals with MASLD. In multivariate weighted logistic regression analysis, the odds ratio (OR) of DII is 1.17 (95% CI: 1.03-1.38) for stroke, with a turning point of 1.89. After the turning point, the OR (95% CI) was 1.22 (1.08-2.56). In subgroup analysis, DII still increased the risk of stroke independently.

Conclusion: Our study highlighted a J-shaped association between DII and stroke in adults with MASLD from USA.

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患有代谢功能障碍相关脂肪性肝病的美国成年人的膳食炎症指数与中风之间存在非线性关系。

背景：一些研究发现，高膳食炎症指数（DII）会增加中风风险，但以往的研究大多是在普通人群中进行的，代谢功能障碍相关脂肪性肝病（MASLD）患者的DII与中风之间的确切关系尚不清楚：本横断面研究利用美国国家健康与营养调查（2009-2016 年）的数据，调查 DII 与中风之间的关系。DII 按照既定方法计算。参与者被分为 DII 的三等分（Q1-Q3）。采用多变量加权逻辑回归分析、平滑曲线拟合和亚组分析来探讨这种关系。根据人口统计学和临床变量进行了分组分析：共有 2426 人参与了研究。结果：共有 2426 人参与了我们的研究，研究人群中中风的总发病率为 4.66%。平滑曲线拟合分析表明，在 MASLD 患者中，DII 与中风的关系呈 "J "形。在多变量加权逻辑回归分析中，DII 与中风的几率比（OR）为 1.17（95% CI：1.03-1.38），转折点为 1.89。转折点之后，OR（95% CI）为 1.22（1.08-2.56）。在亚组分析中，DII 仍会独立增加中风风险：我们的研究表明，在美国患有 MASLD 的成人中，DII 与中风之间存在 J 型关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Gastroenterology & Hepatology 医学-胃肠肝病学

CiteScore

4.40

自引率

4.80%

发文量

269

审稿时长

1 months

期刊介绍： European Journal of Gastroenterology & Hepatology publishes papers reporting original clinical and scientific research which are of a high standard and which contribute to the advancement of knowledge in the field of gastroenterology and hepatology. The journal publishes three types of manuscript: in-depth reviews (by invitation only), full papers and case reports. Manuscripts submitted to the journal will be accepted on the understanding that the author has not previously submitted the paper to another journal or had the material published elsewhere. Authors are asked to disclose any affiliations, including financial, consultant, or institutional associations, that might lead to bias or a conflict of interest.