Investigating the dysregulation of genes associated with glucose and lipid metabolism in gastric cancer and their influence on immunity and prognosis.

IF 5 3区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

BioFactors Pub Date : 2024-11-07 DOI:10.1002/biof.2138

Yan Li, Zhaolin Zeng

引用次数: 0

Abstract

Gastric cancer (GC) is one of the most prevalent malignant tumors globally, characterized by a high mortality rate. The disruption of glucose and lipid metabolism plays a critical role in the occurrence and progression of GC. By integrating single-cell and bulk RNA sequencing data, we identified 135 marker genes associated with glucose and lipid metabolism in GC. Building on this, we conducted prognosis and immune-related analyses, followed by cluster analysis that depicted various molecular subtypes, elucidating their distinct molecular mechanisms and treatment strategies. This includes examining how genes related to glucose and lipid metabolism influence GC prognosis through immune pathways. Additionally, we established a clinical prognostic model characterized by THRAP3, KLF5, and ABCA1. Notably, the core target gene ABCA1 may serve as a prognostic and immunotherapy biomarker for GC.

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研究胃癌葡萄糖和脂质代谢相关基因的失调及其对免疫和预后的影响。

胃癌（GC）是全球发病率最高的恶性肿瘤之一，死亡率很高。葡萄糖和脂质代谢紊乱在胃癌的发生和发展中起着至关重要的作用。通过整合单细胞和大量 RNA 测序数据，我们发现了 135 个与 GC 中糖和脂代谢相关的标记基因。在此基础上，我们进行了预后和免疫相关分析，然后通过聚类分析描绘了各种分子亚型，阐明了其不同的分子机制和治疗策略。这包括研究与葡萄糖和脂质代谢相关的基因如何通过免疫途径影响 GC 的预后。此外，我们还建立了以 THRAP3、KLF5 和 ABCA1 为特征的临床预后模型。值得注意的是，核心靶基因 ABCA1 可作为 GC 的预后和免疫治疗生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BioFactors 生物-内分泌学与代谢

CiteScore

11.50

自引率

3.30%

发文量

审稿时长

6-12 weeks

期刊介绍： BioFactors, a journal of the International Union of Biochemistry and Molecular Biology, is devoted to the rapid publication of highly significant original research articles and reviews in experimental biology in health and disease. The word “biofactors” refers to the many compounds that regulate biological functions. Biological factors comprise many molecules produced or modified by living organisms, and present in many essential systems like the blood, the nervous or immunological systems. A non-exhaustive list of biological factors includes neurotransmitters, cytokines, chemokines, hormones, coagulation factors, transcription factors, signaling molecules, receptor ligands and many more. In the group of biofactors we can accommodate several classical molecules not synthetized in the body such as vitamins, micronutrients or essential trace elements. In keeping with this unified view of biochemistry, BioFactors publishes research dealing with the identification of new substances and the elucidation of their functions at the biophysical, biochemical, cellular and human level as well as studies revealing novel functions of already known biofactors. The journal encourages the submission of studies that use biochemistry, biophysics, cell and molecular biology and/or cell signaling approaches.