Surface-induced self-assembly of peptides turns superhydrophobic surface of electrospun fibrous into superhydrophilic one.

IF 5.4 2区 医学 Q1 BIOPHYSICS
Xuan Sun, Han Ren, Yue-Chan Cui, Qian Liu, Jie Li, Jie Gao
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引用次数: 0

Abstract

Current surface modification strategies for electrospun materials always require covalent conjugation technology, which is relatively inefficient and might damage the bioactivity and structure of peptides and proteins. Here we introduce the use of surface-induced self-assembly technology to modify electrospun materials, which is a simple but efficient noncovalent-based process. Results show that the peptide NapFFGRGD forms burr-like structures on the surface of PCL fibers, reducing the water contact angle of the fibers. Adjusting the peptide sequence and salt concentration affects the self-assembly and surface properties of modified PCL fibers. Additionally, we demonstrate the potential application of this surface modification technique for enhancing cellular responses in tissue engineering applications. The research provides valuable insights into the surface modification of PCL fibers and offers a new method for improving the biological compatibility of materials in tissue engineering.

表面诱导的多肽自组装将电纺纤维的超疏水表面变成超亲水表面。
目前的电纺材料表面改性策略总是需要共价连接技术,这种技术效率相对较低,而且可能会破坏肽和蛋白质的生物活性和结构。在这里,我们介绍使用表面诱导自组装技术来改性电纺材料,这是一种简单而高效的非共价过程。结果表明,多肽 NapFFGRGD 在 PCL 纤维表面形成了毛刺状结构,降低了纤维的水接触角。调整肽序列和盐浓度会影响改性 PCL 纤维的自组装和表面特性。此外,我们还展示了这种表面改性技术在组织工程应用中增强细胞反应的潜在应用。这项研究为 PCL 纤维的表面改性提供了宝贵的见解,并为改善组织工程中材料的生物相容性提供了一种新方法。
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来源期刊
Colloids and Surfaces B: Biointerfaces
Colloids and Surfaces B: Biointerfaces 生物-材料科学:生物材料
CiteScore
11.10
自引率
3.40%
发文量
730
审稿时长
42 days
期刊介绍: Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.
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