Injectable Hydrogels for Programmable Nanoparticle Release

IF 5.1 Q1 POLYMER SCIENCE

ACS Macro Letters Pub Date : 2024-11-13 DOI:10.1002/adfm.202409796

Wenting Shi, Xi Ying, Xinyi Sheng, Soumen Das, Dongjing He, Kasie Collins, Yuhang Hu, M.G. Finn

引用次数: 0

Abstract

Injectable hydrogels represent a promising strategy for the extended release of biological molecules, thereby reducing the frequency of injections. This study introduces a novel system based on Michael addition of dextran and polyethylene glycol (PEG) polymers functionalized with oxanorbornadiene (OND) and thiol groups, respectively. Reliable control over gelation speed allows administration by injection using a simple syringe-to-syringe mixing protocol that entrains more than 95% of virus-like particle (VLP) cargo. A combination of retro-Diels-Alder and hydrolytic ester bond cleavage gives rise to programmable release of the VLPs. Different release profiles, including burst, linear, and delayed release over a two-week period, are engineered using different OND linkages, and rheological characterization shows the hydrogels to be well within the desired range of stiffness for subcutaneous use. The modular nature of this system offers a generalizable platform for developing degradable materials aimed at sustained release biomedical applications.

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用于可编程纳米粒子释放的可注射水凝胶

可注射水凝胶是延长生物分子释放时间，从而减少注射次数的一种有前途的策略。本研究介绍了一种新型系统，该系统基于迈克尔添加葡聚糖和聚乙二醇（PEG）聚合物，这两种聚合物分别具有氧代降冰片烯（OND）和硫醇基团的功能。通过对凝胶化速度的可靠控制，可以使用简单的注射器-注射器混合方案进行注射给药，从而夹带 95% 以上的病毒样颗粒 (VLP) 货物。逆狄尔斯-阿尔德（retro-Diels-Alder）和水解酯键裂解相结合，可实现可编程的 VLP 释放。利用不同的OND连接设计出了不同的释放曲线，包括两周内的爆发释放、线性释放和延迟释放，流变学表征显示水凝胶的硬度完全符合皮下使用的理想范围。该系统的模块化特性为开发可降解材料提供了一个通用平台，可用于持续释放的生物医学应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Macro Letters 化学-

CiteScore

10.40

自引率

3.40%

发文量

209

审稿时长

1 months

期刊介绍： ACS Macro Letters publishes research in all areas of contemporary soft matter science in which macromolecules play a key role, including nanotechnology, self-assembly, supramolecular chemistry, biomaterials, energy generation and storage, and renewable/sustainable materials. Submissions to ACS Macro Letters should justify clearly the rapid disclosure of the key elements of the study. The scope of the journal includes high-impact research of broad interest in all areas of polymer science and engineering, including cross-disciplinary research that interfaces with polymer science. With the launch of ACS Macro Letters, all Communications that were formerly published in Macromolecules and Biomacromolecules will be published as Letters in ACS Macro Letters.