A High-Stability Pressure-Sensitive Implantable Memristor for Pulmonary Hypertension Monitoring

Abstract

Pulmonary hypertension (PH) significantly affects the quality of life and lifespan of humans and has promoted the development of flexible implantable electronic devices for PH diagnosis and prevention. Traditional implantable devices based on the von Neumann architecture face insurmountable challenges in processing large amounts of biological data due to computational bottlenecks. Memristors, with integrated in-memory sensing and computing capabilities, can effectively eliminate computational bottlenecks and become one of the most promising products in implantable devices for health monitoring. Here, a memristor with the Ag/MnO₂/BaTiO₃/FTO structure is implemented and implanted into Sprague‒Dawley (SD) rats. With polydimethylsiloxane (PDMS) packaging, the device can be continuously worked in vivo for up to four weeks, demonstrating excellent stability and biocompatibility. Furthermore, a memristive sensor array is designed for pulmonary artery blood pressure monitoring based on the pressure-responsive characteristics of the as-prepared memristive device. The front-end memristive sensor array can collect and feedback pressure signal, while noise reduction is achieved through memristive logic circuits, and ultimately the memristor neural network processes and classifies the information. Therefore, this work demonstrates the potential of implantable memristors for pulmonary artery pressure monitoring and provides new inspiration for the design of efficient, real-time, and reliable implantable pressure monitoring devices in medical health monitoring.