Dendritic, Water-Soluble, and Nonaggregated Axially Substituted Silicon Phthalocyanine as Potential Endometrial Anticancer Agent

IF 3.7 2区化学 Q2 CHEMISTRY, APPLIED

Applied Organometallic Chemistry Pub Date : 2024-08-15 DOI:10.1002/aoc.7699

Turgut Keles, Gökçe Seyhan, Zekeriya Biyiklioglu, Kübra Kolci, Rengin Reis, Burak Barut

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Abstract

In this work, dendritic, water-soluble, and nonaggregated axially substituted silicon phthalocyanines (EA-TD-Si and EA-TD-SiQ) were synthesized and characterized. Then, the supercoiled pBR322 plasmid DNA damage properties of EA-TD-Si and EA-TD-SiQ were examined using agarose gel electrophoresis without light irradiation. In addition, the cytotoxicity and phototoxicity of EA-TD-Si and EA-TD-SiQ on human endometrium adenocarcinoma (HEC-1B) cells were investigated using an MTT assay. The results indicated that EA-TD-SiQ had high photodamage properties via singlet oxygen depending on the light dose, while EA-TD-Si did not show any DNA damage without light. In addition, EA-TD-SiQ had higher phototoxic effects than EA-TD-Si on HEC-1B cells according to the MTT assay. These results revealed the potential of EA-TD-SiQ to be used as a PDT agent in endometrial cancer.

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作为潜在子宫内膜抗癌剂的树枝状、水溶性和非聚集轴向取代硅酞菁

本研究合成了树枝状、水溶性和非聚集轴向取代硅酞菁（EA-TD-Si 和 EA-TD-SiQ），并对其进行了表征。然后，使用琼脂糖凝胶电泳法检测了 EA-TD-Si 和 EA-TD-SiQ 在无光照射条件下对 pBR322 质粒 DNA 的超卷曲损伤特性。此外，还利用 MTT 试验研究了 EA-TD-Si 和 EA-TD-SiQ 对人类子宫内膜腺癌（HEC-1B）细胞的细胞毒性和光毒性。结果表明，根据光剂量的不同，EA-TD-SiQ 通过单线态氧具有较高的光损伤特性，而 EA-TD-Si 在没有光的情况下不会出现任何 DNA 损伤。此外，根据 MTT 试验，EA-TD-SiQ 对 HEC-1B 细胞的光毒性效应高于 EA-TD-Si。这些结果表明，EA-TD-SiQ 有可能被用作子宫内膜癌的光动力疗法药物。

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来源期刊

Applied Organometallic Chemistry 化学-无机化学与核化学

CiteScore

7.80

自引率

10.30%

发文量

408

审稿时长

2.2 months

期刊介绍： All new compounds should be satisfactorily identified and proof of their structure given according to generally accepted standards. Structural reports, such as papers exclusively dealing with synthesis and characterization, analytical techniques, or X-ray diffraction studies of metal-organic or organometallic compounds will not be considered. The editors reserve the right to refuse without peer review any manuscript that does not comply with the aims and scope of the journal. Applied Organometallic Chemistry publishes Full Papers, Reviews, Mini Reviews and Communications of scientific research in all areas of organometallic and metal-organic chemistry involving main group metals, transition metals, lanthanides and actinides. All contributions should contain an explicit application of novel compounds, for instance in materials science, nano science, catalysis, chemical vapour deposition, metal-mediated organic synthesis, polymers, bio-organometallics, metallo-therapy, metallo-diagnostics and medicine. Reviews of books covering aspects of the fields of focus are also published.