Mechanical properties and development of silver Nanoparticle-enhanced Alginate-polyacrylamide double network Hydrogel

IF 2.6 4区化学 Q3 POLYMER SCIENCE

Journal of Polymer Research Pub Date : 2024-11-11 DOI:10.1007/s10965-024-04188-w

Ghasem Rezanejade Bardajee, Nastaran Dianatnejad, Nosrat O. Mahmoodi, Hossein Mahmoodain

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Abstract

This study investigates the enhancement of mechanical properties in a sodium alginate-polyacrylamide double network (DN) nanocomposite hydrogel enhanced with silver nanoparticles (Alg-g-PAAm/nAg). This hydrogel utilizes both thermal and ionic cross-linking methods (MBA and CaCl₂) to develop a robust matrix with outstanding mechanical and thermal properties. The Alg-g-PAAm/nAg DN nanocomposite hydrogel demonstrated a fracture stress of 1255 kPa, an elastic modulus of 200 kPa, and an exceptional toughness value of 520,000 kJ/m³. Furthermore, the material’s response to swelling in various pH and temperatures was analyzed through swelling studies, revealing significant pH sensitivity. The incorporation of silver nanoparticles (Ag NPs) within the nanocomposite significantly enhanced both its mechanical strength and stability, as well as its antibacterial performance. Antimicrobial assays against Staphylococcus aureus and Escherichia coli demonstrated pronounced inhibition zones, indicating the hydrogel’s potent antibacterial properties. This dual enhancement makes the composite highly suitable for various demanding biomedical applications. The comprehensive analytical techniques employed, including FT-IR, FE-SEM, TEM, and TGA, confirmed the successful integration of the Ag NPs within the nanocomposite structure and underscored the material’s potential in fields such as tissue engineering, drug delivery systems, and advanced wound dressings.

Graphical Abstract

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银纳米粒子增强型藻酸盐-聚丙烯酰胺双网络水凝胶的力学性能与开发

本研究探讨了用银纳米粒子（Alg-g-PAAm/nAg）增强海藻酸钠-聚丙烯酰胺双网络（DN）纳米复合水凝胶机械性能的问题。这种水凝胶采用热交联和离子交联方法（MBA 和 CaCl2）来开发具有出色机械性能和热性能的坚固基质。Alg-g-PAAm/nAg DN 纳米复合水凝胶的断裂应力为 1255 kPa，弹性模量为 200 kPa，韧性值高达 520,000 kJ/m³。此外，还通过溶胀研究分析了材料在不同 pH 值和温度下的溶胀反应，结果表明其对 pH 值非常敏感。在纳米复合材料中加入银纳米粒子（Ag NPs）后，材料的机械强度和稳定性以及抗菌性能都得到了显著提高。针对金黄色葡萄球菌和大肠杆菌的抗菌试验显示了明显的抑菌区，表明水凝胶具有强大的抗菌性能。这种双重增强特性使该复合材料非常适合各种高要求的生物医学应用。所采用的傅立叶变换红外光谱、FE-SEM、TEM 和 TGA 等综合分析技术证实了 Ag NPs 在纳米复合材料结构中的成功整合，并强调了该材料在组织工程、药物输送系统和先进伤口敷料等领域的潜力。

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来源期刊

Journal of Polymer Research 化学-高分子科学

CiteScore

4.70

自引率

7.10%

发文量

472

审稿时长

3.6 months

期刊介绍： Journal of Polymer Research provides a forum for the prompt publication of articles concerning the fundamental and applied research of polymers. Its great feature lies in the diversity of content which it encompasses, drawing together results from all aspects of polymer science and technology. As polymer research is rapidly growing around the globe, the aim of this journal is to establish itself as a significant information tool not only for the international polymer researchers in academia but also for those working in industry. The scope of the journal covers a wide range of the highly interdisciplinary field of polymer science and technology, including: polymer synthesis; polymer reactions; polymerization kinetics; polymer physics; morphology; structure-property relationships; polymer analysis and characterization; physical and mechanical properties; electrical and optical properties; polymer processing and rheology; application of polymers; supramolecular science of polymers; polymer composites.