Intracellular dark spots are associated with endothelial cell loss after Descemet’s stripping automated endothelial keratoplasty

IF 3.7 2区医学 Q1 OPHTHALMOLOGY

British Journal of Ophthalmology Pub Date : 2024-11-07 DOI:10.1136/bjo-2024-325702

Yurina Mori-Ogiwara, Yukari Yagi-Yaguchi, Osama Ibrahim, Kazunari Higa, Hirotsugu Kasamatsu, Takahiro Kanda, Daisuke Tomida, Yoshinori Oie, Takahiko Hayashi, Jun Shimazaki, Takefumi Yamaguchi

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引用次数: 0

Abstract

Intracellular dark endothelial spots (IDESs) on specular microscopy developed in 78/122 patients (63.9%) after Descemet stripping automated endothelial keratoplasty (DSAEK). Endothelial cell density (ECD) after DSAEK was significantly smaller in eyes with IDES when compared with those without at all time points (p<0.001) despite no significant difference in graft ECD (p=0.43), resulting in an increased rate of endothelial failure (p=0.044). The presence of glaucoma (OR=2.22, p=0.027), iris damage (OR=2.85, p=0.004) and non-Fuchs status (OR=2.37, p=0.018) were identified as risk factors for IDES development. Preoperative total protein level in aqueous humour was significantly higher in eye with endothelial failure than those without (p=0.0057). The data that support the findings of this study are available on request from the corresponding author (TY). The data are not publicly available due to them containing information that could compromise research participant privacy/consent.

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细胞内黑斑与 Descemet 剥离自动内皮角膜移植术后内皮细胞脱落有关

78/122名患者（63.9%）在接受了Descemet剥离自动内皮角膜移植术（DSAEK）后，镜下发现细胞内暗色内皮斑（IDES）。尽管移植物内皮细胞密度（ECD）无显著差异（p=0.43），但在所有时间点上，有内皮细胞密度（ECD）的眼球与无内皮细胞密度（ECD）的眼球相比都明显较小（p<0.001），导致内皮失败率增加（p=0.044）。青光眼（OR=2.22，p=0.027）、虹膜损伤（OR=2.85，p=0.004）和非 Fuchs 状态（OR=2.37，p=0.018）是 IDES 发生的风险因素。有内皮功能衰竭的眼球术前眼房总蛋白水平明显高于无内皮功能衰竭的眼球（p=0.0057）。支持本研究结果的数据可向通讯作者（TY）索取。由于数据中包含的信息可能会损害研究参与者的隐私/同意，因此这些数据不对外公开。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

British Journal of Ophthalmology 医学-眼科学

CiteScore

10.30

自引率

2.40%

发文量

213

审稿时长

3-6 weeks

期刊介绍： The British Journal of Ophthalmology (BJO) is an international peer-reviewed journal for ophthalmologists and visual science specialists. BJO publishes clinical investigations, clinical observations, and clinically relevant laboratory investigations related to ophthalmology. It also provides major reviews and also publishes manuscripts covering regional issues in a global context.