Construction of α‐ketoamides via Photoredox‐Catalyzed N−H Insertion of Amines by Sulfoxonium Ylides

IF 4.4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2024-11-08 DOI:10.1002/adsc.202401020

Xianglin Yu, Haiyue Yang, Chang Liu, Qiping He, Zhijun Yang, Yi Jin

引用次数: 0

Abstract

Herein, we report the development of photoredox‐catalyzed N−H insertion of sulfoxonium ylides with amines via oxidative single‐electron transfer (SET). These reactions exhibit broad substrate scope (32 examples) and offer operationally simple, scalable procedures for accessing α‐ketoamides in a single step. Mechanistic studies and control experiments confirm the participation of a photogenerated carbon radical in facilitating the oxidative single‐electron transfer (SET) from the sulfoxonium ylides to initiate the reaction.

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通过光氧化催化亚磺酸铵N-H插入胺构建α-酮酰胺

在此，我们报告了通过氧化单电子转移 (SET) 光氧催化 N-H 插入胺的磺酸鎓酰化物的研究进展。这些反应具有广泛的底物范围（32 个实例），并提供了操作简单、可扩展的程序，只需一步即可获得 α-酮酰胺。机理研究和对照实验证实，光生碳自由基参与了促进氧化性单电子转移（SET）的过程，从磺鎓酰化物开始启动反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.