A Study Into Systemic and Oral Levels of Proinflammatory Biomarkers Associated With Endpoints After Active Non‐Surgical Periodontal Therapy

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology Pub Date : 2024-11-11 DOI:10.1111/jcpe.14089

Nils Werner, Iris Frasheri, Katrin Heck, Carla Scalia, Vinay Pitchika, Burkhard Summer, Christina Ern, Richard Heym, Falk Schwendicke, Caspar Victor Bumm, Matthias Folwaczny

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引用次数: 0

Abstract

AimTo analyse whether some selected inflammatory biomarkers collected from venous blood and gingival crevicular fluid (GCF) were associated with the outcome of non‐surgical periodontal therapy.Materials and MethodsTwo‐hundred and nine patients affected by periodontitis were enrolled in the study, who had undergone steps I and II therapy as well as a non‐surgical re‐instrumentation (NSRI) of periodontal pockets after 6 months. Serum (SE), plasma (PL) and GCF samples were quantitatively analysed for the following inflammatory biomarkers: active matrix metalloproteinase‐8 (aMMP‐8), prostaglandin E2 (PGE2) and surfactant protein D (SP‐D). Therapy outcomes were evaluated using a ‘treat‐to‐target’ endpoint (T2T) at the patient level, defined as ≤ 4 sites with pocket depth ≥ 5 mm.ResultsPatients presented with 23 ± 6 teeth (mean ± SD) at baseline. After steps I and II therapy, 41.6% of the patients reached T2T and after NSRI 47.4%. Univariate analysis identified a potential association between high levels of PL‐SP‐D and more favourable treatment outcomes. Multivariate binary logistic regression adjusted for sex, mean baseline probing depth, diabetes and current smoking status confirmed an independent relationship between baseline PL‐SP‐D and the T2T after steps I and II therapy (aOR 0.432, p = 0.011), implying that a higher level PL‐SP‐D at baseline is associated with a > 50% reduced risk of failing T2T. However, no such association was found for PL‐SP‐D and NSRI.ConclusionHigher baseline PL‐SP‐D levels might be associated with more favourable treatment outcomes after steps I and II therapy. This may be due to its role in the regulation of neutrophil function. However, further investigation is required to confirm this hypothesis. If proven, PL‐SP‐D could play a role as a biomarker for identifying individuals who respond differentially to primary therapy.

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积极非手术牙周治疗后与终点相关的全身和口腔前炎症生物标志物水平研究

目的分析从静脉血和牙龈缝隙液（GCF）中采集的某些特定炎症生物标志物是否与牙周非手术疗法的结果有关。材料与方法研究纳入了 290 名牙周炎患者，他们接受了第一步和第二步疗法，并在 6 个月后对牙周袋进行了非手术再刺激（NSRI）。对血清 (SE)、血浆 (PL) 和 GCF 样品进行了以下炎症生物标记物的定量分析：活性基质金属蛋白酶-8 (aMMP-8)、前列腺素 E2 (PGE2) 和表面活性蛋白 D (SP-D)。治疗结果采用患者水平的 "治疗到目标 "终点（T2T）进行评估，"治疗到目标 "终点的定义是：牙槽深度≥ 5 毫米的部位≤ 4 个。经过第一步和第二步治疗后，41.6%的患者达到了T2T，经过NSRI治疗后，47.4%的患者达到了T2T。单变量分析发现，高水平的 PL-SP-D 与更有利的治疗结果之间存在潜在联系。多变量二元逻辑回归调整了性别、平均基线探查深度、糖尿病和当前吸烟状况，证实基线 PL-SP-D 与步骤 I 和步骤 II 治疗后的 T2T 之间存在独立关系（aOR 0.432，p = 0.011），这意味着基线 PL-SP-D 水平越高，T2T 失败的风险就会降低 50%。结论较高的基线 PL-SP-D 水平可能与 I 步和 II 步治疗后更有利的治疗结果有关。这可能是由于 PL-SP-D 在中性粒细胞功能调节中的作用。然而，要证实这一假设还需要进一步的研究。如果得到证实，PL-SP-D 可作为一种生物标志物，用于识别对初治有不同反应的个体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Periodontology 医学-牙科与口腔外科

CiteScore

13.30

自引率

10.40%

发文量

175

审稿时长

3-8 weeks

期刊介绍： Journal of Clinical Periodontology was founded by the British, Dutch, French, German, Scandinavian, and Swiss Societies of Periodontology. The aim of the Journal of Clinical Periodontology is to provide the platform for exchange of scientific and clinical progress in the field of Periodontology and allied disciplines, and to do so at the highest possible level. The Journal also aims to facilitate the application of new scientific knowledge to the daily practice of the concerned disciplines and addresses both practicing clinicians and academics. The Journal is the official publication of the European Federation of Periodontology but wishes to retain its international scope. The Journal publishes original contributions of high scientific merit in the fields of periodontology and implant dentistry. Its scope encompasses the physiology and pathology of the periodontium, the tissue integration of dental implants, the biology and the modulation of periodontal and alveolar bone healing and regeneration, diagnosis, epidemiology, prevention and therapy of periodontal disease, the clinical aspects of tooth replacement with dental implants, and the comprehensive rehabilitation of the periodontal patient. Review articles by experts on new developments in basic and applied periodontal science and associated dental disciplines, advances in periodontal or implant techniques and procedures, and case reports which illustrate important new information are also welcome.