BRCA1 and BRCA2: from cancer susceptibility to synthetic lethality

IF 7.5 1区生物学 Q1 CELL BIOLOGY

Genes & development Pub Date : 2024-11-07 DOI:10.1101/gad.352083.124

Anna Khalizieva, Sarah C. Moser, Peter Bouwman, Jos Jonkers

引用次数: 0

Abstract

The discovery of BRCA1 and BRCA2 as tumor susceptibility genes and their role in genome maintenance has transformed our understanding of hereditary breast and ovarian cancer. This review traces the evolution of BRCA1/2 research over the past 30 years, highlighting key discoveries in the field and their contributions to tumor development. Additionally, we discuss current preventive measures for BRCA1/2 mutation carriers and targeted treatment options based on the concept of synthetic lethality. Finally, we explore the challenges of acquired therapy resistance and discuss potential alternative avenues for targeting BRCA1/2 mutant tumors.

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BRCA1 和 BRCA2：从癌症易感性到合成致死性

作为肿瘤易感基因的 BRCA1 和 BRCA2 的发现及其在基因组维护中的作用改变了我们对遗传性乳腺癌和卵巢癌的认识。本综述回顾了过去 30 年中 BRCA1/2 研究的发展历程，重点介绍了该领域的重要发现及其对肿瘤发展的贡献。此外，我们还讨论了目前针对 BRCA1/2 基因突变携带者的预防措施以及基于合成致死概念的靶向治疗方案。最后，我们探讨了获得性耐药性的挑战，并讨论了针对 BRCA1/2 突变肿瘤的潜在替代途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Genes & development 生物-发育生物学

CiteScore

17.50

自引率

1.90%

发文量

审稿时长

3-6 weeks

期刊介绍： Genes & Development is a research journal published in association with The Genetics Society. It publishes high-quality research papers in the areas of molecular biology, molecular genetics, and related fields. The journal features various research formats including Research papers, short Research Communications, and Resource/Methodology papers. Genes & Development has gained recognition and is considered as one of the Top Five Research Journals in the field of Molecular Biology and Genetics. It has an impressive Impact Factor of 12.89. The journal is ranked #2 among Developmental Biology research journals, #5 in Genetics and Heredity, and is among the Top 20 in Cell Biology (according to ISI Journal Citation Reports®, 2021).