Built-in potential-regulated and exogenous excited electrochemiluminescence sensor based on dual-monomers molecularly imprinted polymer for the biomimetic detection of thiabendazole

IF 5.4 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Biomaterials Science & Engineering Pub Date : 2024-11-09 DOI:10.1016/j.foodchem.2024.141984

Wen Hao, Jingwen He, Jie Wu, Lin Cai, Yifei Wang, Guozhen Fang, Shuo Wang

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引用次数: 0

Abstract

Thiabendazole (TBZ) residues in food pose a serious threat to public health. Herein, an ultrasensitive molecularly imprinted electrochemiluminescence sensor (MIECLS) was developed to detect TBZ, using electron autoregulation in nitrogen-doped graphdiyne‑copper nanowires (NGDY-CuNWs) composite luminophore and cyclic amplification strategy of tin disulfide nanosheets (SnS₂NSs). NGDY-CuNWs composite luminophores were formed by spontaneous chemisorption to provide electrochemiluminescence signals, and the charge redistribution in it resulted in a built-in potential that improved the electron transfer and redox reaction rate. The cyclic transformation of electron pairs (Sn²⁺/Sn⁴⁺) on SnS₂NSs catalyzed the generation of sulfate anion radicals to amplify electrochemiluminescence signals. Due to the complementary and synergistic interaction of functional monomers, high affinity imprinted cavities were formed to recognize TBZ. MIECLS had a wide detection range of 1 × 10⁻⁹–1 × 10⁻⁵ mol L⁻¹ with the limit of detection of 1.69 × 10⁻¹⁰ mol L⁻¹ and had huge application potential to detect pesticide residues.

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基于双单体分子印迹聚合物的内置电位调节和外源激发电化学发光传感器用于噻苯咪唑的生物模拟检测

食品中的噻苯咪唑（TBZ）残留对公众健康构成严重威胁。本文利用掺氮石墨二乙烯-铜纳米线（NGDY-CuNWs）复合发光体中的电子自调节和二硫化锡纳米片（SnS2NSs）的循环放大策略，开发了一种超灵敏分子印迹电化学发光传感器（MIECLS）来检测TBZ。NGDY-CuNWs 复合发光体是通过自发化学吸附作用形成的，可提供电化学发光信号，其中的电荷再分布产生的内置电势提高了电子转移和氧化还原反应速率。SnS2NSs 上电子对（Sn2+/Sn4+）的循环转化催化了硫酸根阴离子自由基的生成，从而放大了电致发光信号。由于功能单体之间的互补和协同作用，形成了高亲和力的印迹空腔，可识别 TBZ。MIECLS 的检测范围为 1 × 10-9-1 × 10-5 mol L-1，检测限为 1.69 × 10-10 mol L-1，在检测农药残留方面具有巨大的应用潜力。

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来源期刊

ACS Biomaterials Science & Engineering Materials Science-Biomaterials

CiteScore

10.30

自引率

3.40%

发文量

413

期刊介绍： ACS Biomaterials Science & Engineering is the leading journal in the field of biomaterials, serving as an international forum for publishing cutting-edge research and innovative ideas on a broad range of topics: Applications and Health – implantable tissues and devices, prosthesis, health risks, toxicology Bio-interactions and Bio-compatibility – material-biology interactions, chemical/morphological/structural communication, mechanobiology, signaling and biological responses, immuno-engineering, calcification, coatings, corrosion and degradation of biomaterials and devices, biophysical regulation of cell functions Characterization, Synthesis, and Modification – new biomaterials, bioinspired and biomimetic approaches to biomaterials, exploiting structural hierarchy and architectural control, combinatorial strategies for biomaterials discovery, genetic biomaterials design, synthetic biology, new composite systems, bionics, polymer synthesis Controlled Release and Delivery Systems – biomaterial-based drug and gene delivery, bio-responsive delivery of regulatory molecules, pharmaceutical engineering Healthcare Advances – clinical translation, regulatory issues, patient safety, emerging trends Imaging and Diagnostics – imaging agents and probes, theranostics, biosensors, monitoring Manufacturing and Technology – 3D printing, inks, organ-on-a-chip, bioreactor/perfusion systems, microdevices, BioMEMS, optics and electronics interfaces with biomaterials, systems integration Modeling and Informatics Tools – scaling methods to guide biomaterial design, predictive algorithms for structure-function, biomechanics, integrating bioinformatics with biomaterials discovery, metabolomics in the context of biomaterials Tissue Engineering and Regenerative Medicine – basic and applied studies, cell therapies, scaffolds, vascularization, bioartificial organs, transplantation and functionality, cellular agriculture