A framework for translational therapy development in deep brain stimulation

IF 6.7 1区医学 Q1 NEUROSCIENCES

NPJ Parkinson's Disease Pub Date : 2024-11-08 DOI:10.1038/s41531-024-00829-5

Jia Zhi Chen, Jens Volkmann, Chi Wang Ip

引用次数: 0

Abstract

Deep brain stimulation (DBS) is an established treatment for motor disorders like Parkinson’s disease, but its mechanisms and effects on neurons and networks are not fully understood, limiting research-driven progress. This review presents a framework that combines neurophysiological insights and translational research to enhance DBS therapy, emphasizing biomarkers, device technology, and symptom-specific neuromodulation. It also examines the role of animal research in improving DBS, while acknowledging challenges in clinical translation.

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脑深部刺激转化疗法开发框架

脑深部刺激（DBS）是一种治疗帕金森病等运动障碍的成熟疗法，但其机制及其对神经元和网络的影响尚未完全明了，从而限制了研究的进展。本综述提出了一个将神经生理学见解和转化研究相结合的框架，以加强 DBS 治疗，强调生物标志物、设备技术和症状特异性神经调节。它还探讨了动物研究在改进 DBS 方面的作用，同时也承认了临床转化所面临的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NPJ Parkinson's Disease Medicine-Neurology (clinical)

CiteScore

9.80

自引率

5.70%

发文量

156

审稿时长

11 weeks

期刊介绍： npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.