Synthesis of Amide-Containing Indolo[2,1-a]isoquinoline Derivatives via Palladium-Catalyzed Cascade Reactions

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2024-11-08 DOI:10.1021/acs.joc.4c02069

Jianyi Ma, Leming Wang, Shufeng Chen

引用次数: 0

Abstract

A convenient palladium-catalyzed cascade cyclization reaction for the construction of amide-containing indolo[2,1-a]isoquinolines from 2-aryl-N-propenyl indoles with aromatic amines and chloroform is described. A variety of amide-containing indolo[2,1-a]isoquinoline compounds have been successfully synthesized in moderate to good yields in which chloroform is employed as the source of CO.

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通过钯催化级联反应合成含酰胺的吲哚并[2,1-a]异喹啉衍生物

本研究描述了一种方便的钯催化级联环化反应，该反应以 2-芳基-N-丙烯基吲哚为原料，通过芳香胺和氯仿构建含酰胺的吲哚并[2,1-a]异喹啉化合物。在氯仿作为 CO 源的条件下，成功合成了多种含酰胺的吲哚并[2,1-a]异喹啉化合物，收率从中等到良好。

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.