Exploring the clinical potential of circulating LncRNAs in breast cancer: insights into primary signaling pathways and therapeutic interventions

IF 3.9 4区生物学 Q1 GENETICS & HEREDITY

Functional & Integrative Genomics Pub Date : 2024-11-07 DOI:10.1007/s10142-024-01476-y

Tohada M. AL-Noshokaty, Rehab Abdelhamid, Tasnim Reda, Ayat Alaaeldien, Nourhan Abdellatif, Abdallah Mansour, David Gendi, Nourhan M. Abdelmaksoud, Shereen Saeid Elshaer, Ahmed S. Doghish, Mohamed Hossam Sobhy, Osama A. Mohammed, Ahmed I. Abulsoud

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Abstract

Breast cancer (BC) occupies the top spot among women on a global scale. The tumor has a significant degree of heterogeneity, displaying a notable prevalence of medication resistance, recurrence, and metastasis, rendering it one of the most lethal forms of malignant neoplasms. The timely identification, ongoing evaluation of therapeutic interventions, and accurate prediction of outcomes play crucial roles in determining the overall survival rates of women with BC. Nevertheless, the absence of precise biomarkers remains a significant determinant impacting the overall well-being and both the physical and emotional health of BC patients. Long noncoding RNA (lncRNA) exerts regulatory control over several genes and signaling pathways, hence assuming crucial roles in the development of neoplastic growth. Recently, research has indicated that the atypical expression of circulating lncRNAs in various biological bodily fluids has a noteworthy impact on the early detection, pathological categorization, staging, monitoring of therapy outcomes, and evaluation of prognosis in cases of BC. This article aims to assess the potential clinical utility of circulating lncRNAs in the context of BC focusing on specific primary signaling pathways; Wnt/β-catenin, Notch, TGF-β, and hedgehog (Hh), in addition to some therapeutic interventions.

Graphical Abstract

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探索乳腺癌中循环 LncRNA 的临床潜力：深入了解主要信号通路和治疗干预措施

乳腺癌（BC）是全球妇女的头号杀手。这种肿瘤具有很大程度的异质性，耐药、复发和转移现象明显，是最致命的恶性肿瘤之一。及时发现、持续评估治疗干预措施以及准确预测预后，对决定 BC 女性患者的总体生存率起着至关重要的作用。然而，缺乏精确的生物标志物仍然是影响 BC 患者整体福祉和身心健康的重要决定因素。长非编码 RNA（lncRNA）对多个基因和信号通路具有调控作用，因此在肿瘤生长过程中起着至关重要的作用。最近的研究表明，循环lncRNA在各种生物体液中的非典型表达对BC病例的早期检测、病理分类、分期、治疗效果监测和预后评估有显著影响。本文旨在评估循环lncRNAs在BC中的潜在临床应用，重点关注特定的主要信号通路：Wnt/β-catenin、Notch、TGF-β和hedgehog (Hh)，以及一些治疗干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Functional & Integrative Genomics 生物-遗传学

CiteScore

3.50

自引率

3.40%

发文量

审稿时长

2 months

期刊介绍： Functional & Integrative Genomics is devoted to large-scale studies of genomes and their functions, including systems analyses of biological processes. The journal will provide the research community an integrated platform where researchers can share, review and discuss their findings on important biological questions that will ultimately enable us to answer the fundamental question: How do genomes work?