Copper(II) 2-(N-Tosylamino)benzaldehyde Benzoylhydrazone Complexes: Synthesis, Structures, Properties, and Biological Activity

IF 1.1 3区化学 Q4 CHEMISTRY, INORGANIC & NUCLEAR

Russian Journal of Coordination Chemistry Pub Date : 2024-11-07 DOI:10.1134/S1070328424600438

B. V. Chal’tsev, A. S. Burlov, V. G. Vlasenko, Yu. V. Koshchienko, A. A. Zubenko, A. I. Klimenko, V. A. Lazarenko, S. A. Mashchenko, E. V. Korshunova, T. V. Lifintseva

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Abstract

A number of new copper(II) complexes of 2-(N-tosylamino)benzaldehyde benzoylhydrazone (H₂L) CuLLⁿ (n = 1–6) with heterocyclic donor ligands (L¹ = 1-propyl-2-aminobenzimidazole, L² = 1‑hexyl-2-aminobenzimidazole, L³ = 1-octyl-2-aminobenzimidazole, L⁴ = 2,2'-bipyridine, L⁵ = 1,10-phenanthroline, and L⁶ = 2-aminopyridine) is synthesized. The structures and compositions of the synthesized compounds are determined by elemental analysis, ¹Н NMR spectroscopy, IR spectroscopy, and magnetochemistry. The molecular structures of complexes CuLL^1,2,4−6 are determined by XRD (CIF files CCDC nos. 2341480 (CuLL¹), 2341468 (CuLL²), 2341478 (CuLL⁴), 2341477 (CuLL⁵), and 2341479 (CuLL⁶)). The biological activity of the complexes is studied. The adducts with L¹, L², and L⁶ exhibit a significantly higher anti-protist activity than chloroquine used as the reference compound.

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2-(N-对甲苯磺酰基氨基)苯甲醛苯甲酰腙铜(II)配合物：合成、结构、性质和生物活性

2-(N-对甲苯磺酸氨基)苯甲醛苯甲酰腙（H2L）CuLLn（n = 1-6）与杂环供体配体（L1 = 1-丙基-2-氨基苯并咪唑、L2 = 1-己基-2-氨基苯并咪唑、L3 = 1-辛基-2-氨基苯并咪唑、L4 = 2,2'-联吡啶、L5 = 1,10-菲罗啉和 L6 = 2-氨基吡啶）合成。通过元素分析、1Н NMR 光谱、红外光谱和磁化学分析确定了合成化合物的结构和组成。复合物 CuLL1、2、4-6 的分子结构通过 XRD（CIF 文件 CCDC 编号：2341480（CuLL1）、2341468（CuLL2）、2341478（CuLL4）、2341477（CuLL5）和 2341479（CuLL6））确定。研究了这些复合物的生物活性。与用作参考化合物的氯喹相比，L1、L2 和 L6 的加合物具有更高的抗原虫活性。

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来源期刊

Russian Journal of Coordination Chemistry 化学-无机化学与核化学

CiteScore

2.40

自引率

15.80%

发文量

审稿时长

7.2 months

期刊介绍： Russian Journal of Coordination Chemistry is a journal that publishes reviews, original papers, and short communications on all aspects of theoretical and experimental coordination chemistry. Modern coordination chemistry is an interdisciplinary science that makes a bridge between inorganic, organic, physical, analytical, and biological chemistry.