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{"title":"Cu-miRNA stress relievers","authors":"Jun Lyu","doi":"10.1038/s41477-024-01868-9","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":18904,"journal":{"name":"Nature Plants","volume":"10 11","pages":"1616-1616"},"PeriodicalIF":15.8000,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Plants","FirstCategoryId":"99","ListUrlMain":"https://www.nature.com/articles/s41477-024-01868-9","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PLANT SCIENCES","Score":null,"Total":0}
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Cu-miRNA 压力缓解剂
许多 LACs 受铜-miRNAs(Cu-miRNAs)调控,铜-miRNAs 以编码含铜蛋白质的基因为靶标。LACs是植物木质化和黄酮类化合物合成所必需的,与植物的生长发育和抗逆性有关。因此,研究人员研究了操纵 Cu-miRNA 对抗逆性的影响。具体来说,他们选择了三个Cu-miRNA(miR397、miR408和miR528),因为这三个基因共同靶向水稻28个LAC家族基因中的18个。同时在水稻(3miR-OE)中过表达这三个 Cu-miRNAs 会导致 LACs 大量沉默,降低漆酶活性和木质素含量,而敲除这三个 miRNAs 则会产生相反的表型。3miR-OE 植物的代谢组显示,木质素途径的产物减少了,但黄酮类代谢物却显著增加。因此,过表达这三个 miRNA 会使水稻的代谢从木质素合成转向黄酮类化合物的积累。
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