All roads lead to cholesterol: Modulating lipid biosynthesis in multiple sclerosis patient-derived models

IF 19.8 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2024-11-07 DOI:10.1016/j.stem.2024.10.011

Sophie Eichhorner, Larissa Traxler, Oliver Borgogno, Jerome Mertens

引用次数: 0

Abstract

Studies from Ionescu et al.¹ and Clayton et al.² using multiple sclerosis (MS) patient-derived cell models underscore cholesterol metabolism’s role in inflammatory and dysfunctional cell phenotypes in the disease. Inhibiting cholesterol biosynthesis ameliorated critical cellular phenotypes, emphasizing the need to further investigate this pathway as a potential target for MS treatment.

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条条大路通罗马调节多发性硬化症患者衍生模型中的脂质生物合成

Ionescu 等人1 和 Clayton 等人2 利用多发性硬化症（MS）患者衍生细胞模型进行的研究强调了胆固醇代谢在该疾病的炎症和功能障碍细胞表型中的作用。抑制胆固醇的生物合成可以改善关键的细胞表型，这强调了进一步研究这一途径作为治疗多发性硬化症潜在靶点的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.