Effects of loxoprofen on impaired water-evoked swallows in a pharyngitis rat model

IF 2.2 4区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Archives of oral biology Pub Date : 2024-11-02 DOI:10.1016/j.archoralbio.2024.106125

Mari Fukuzaki , Chihiro Nakatomi , Sayaka Kubo , Tomoki Shimada , Keiko Tsuji , Chia-Chien Hsu , Tatsuo Kawamoto , Kentaro Ono

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引用次数: 0

Abstract

Objective

The objective of this study was to investigate the effects of nonsteroidal anti-inflammatory drugs (NSAIDs; e.g., loxoprofen) on pharyngitis-induced dysphagia in rats.

Design

A pharyngitis rat model was generated by topical application of acetic acid to the laryngopharyngeal region. Changes in water swallowing were evaluated by endoscopic observation over time. A histological analysis of the laryngopharyngeal mucosa was performed. The effects of loxoprofen, antibacterial drugs, and transient receptor potential (TRP) channel inhibitors were investigated in model rats.

Results

After acetic acid treatment, water-evoked swallowing was impaired on day 1 (prolonging the swallowing latency and interval and decreasing the number of swallows), and recovered until day 6. Administration of loxoprofen significantly alleviated impaired water swallowing. Histologically, loxoprofen significantly improved inflammation of the pharynx, including submucosal edema, but did not affect the loss of taste bud-like structures in the arytenoid. In contrast, the administration of antibacterial drugs or TRP channel inhibitors did not affect the impairment of water swallowing in the model group.

Conclusion

These results demonstrate the efficacy of systemic administration of loxoprofen in improving swallowing impairment in a pharyngitis model rat. This study is the first to provide scientific evidence for the use of NSAIDs in the management of pharyngitis.

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洛索洛芬对咽炎大鼠模型水诱发吞咽功能受损的影响

本研究旨在探讨非甾体抗炎药（NSAIDs，如洛索洛芬）对咽炎引起的大鼠吞咽困难的影响。设计通过在喉咽部局部施用醋酸建立咽炎大鼠模型。通过内窥镜观察评估吞水量随时间的变化。对喉咽粘膜进行了组织学分析。结果经醋酸处理后，吞咽水的能力在第 1 天受到影响（吞咽潜伏期和间隔时间延长，吞咽次数减少），直到第 6 天才恢复。服用洛索洛芬可明显缓解吞水障碍。从组织学角度来看，洛索洛芬能明显改善咽部炎症，包括粘膜下水肿，但不会影响杓状体味蕾样结构的丧失。相比之下，服用抗菌药物或 TRP 通道抑制剂对模型组的吞水障碍没有影响。这项研究首次为非甾体抗炎药治疗咽炎提供了科学证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of oral biology 医学-牙科与口腔外科

CiteScore

5.10

自引率

3.30%

发文量

177

审稿时长

26 days

期刊介绍： Archives of Oral Biology is an international journal which aims to publish papers of the highest scientific quality in the oral and craniofacial sciences. The journal is particularly interested in research which advances knowledge in the mechanisms of craniofacial development and disease, including: Cell and molecular biology Molecular genetics Immunology Pathogenesis Cellular microbiology Embryology Syndromology Forensic dentistry