Recent advances in coaxial electrospun nanofibers for wound healing

IF 8.7 1区医学 Q1 ENGINEERING, BIOMEDICAL

Materials Today Bio Pub Date : 2024-10-26 DOI:10.1016/j.mtbio.2024.101309

Jing Zhao , Liyun Chen , Aiwei Ma , Xujue Bai , Yating Zeng , Daojun Liu , Bo Liu , Wancong Zhang , Shijie Tang

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Abstract

The skin is the body's primary immune barrier, defending it against pathogenic invasion. Skin injuries impose a significant physiological burden on patients, making effective wound management essential. Dressings are commonly employed in wound care, and electrospun nanofiber dressings are a research hotspot owing to their ease of fabrication, cost-effectiveness, and structural similarity to the extracellular matrix. Coaxial electrospinning offers considerable advantages in drug delivery, fiber structure transformation, and enhanced interaction with the host. These attributes make coaxial electrospun materials promising candidates for precision and personalized wound dressings in medical treatments. This review provides a comprehensive overview of wound healing and its influencing factors. It also outlines coaxial electrospinning's production principles and benefits in wound dressings. Guided by the factors affecting wound healing, coaxial electrospun nanofiber dressings have different application modalities. Furthermore, we discuss the current limitations and future directions for enhancing the current coaxial electrospun dressing technologies.

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用于伤口愈合的同轴电纺纳米纤维的最新进展

皮肤是人体的主要免疫屏障，可抵御病原体的入侵。皮肤损伤给患者带来了巨大的生理负担，因此有效的伤口管理至关重要。敷料通常用于伤口护理，而电纺纳米纤维敷料因其易于制造、成本效益高以及与细胞外基质结构相似而成为研究热点。同轴电纺在药物输送、纤维结构转换和增强与宿主的相互作用方面具有相当大的优势。这些特性使得同轴电纺材料有望成为医疗中精确和个性化伤口敷料的候选材料。本综述全面概述了伤口愈合及其影响因素。它还概述了同轴电纺的生产原理以及在伤口敷料中的优势。根据影响伤口愈合的因素，同轴电纺纳米纤维敷料有不同的应用模式。此外，我们还讨论了当前同轴电纺敷料技术的局限性和未来改进方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Materials Today Bio Multiple-

CiteScore

8.30

自引率

4.90%

发文量

303

审稿时长

30 days

期刊介绍： Materials Today Bio is a multidisciplinary journal that specializes in the intersection between biology and materials science, chemistry, physics, engineering, and medicine. It covers various aspects such as the design and assembly of new structures, their interaction with biological systems, functionalization, bioimaging, therapies, and diagnostics in healthcare. The journal aims to showcase the most significant advancements and discoveries in this field. As part of the Materials Today family, Materials Today Bio provides rigorous peer review, quick decision-making, and high visibility for authors. It is indexed in Scopus, PubMed Central, Emerging Sources, Citation Index (ESCI), and Directory of Open Access Journals (DOAJ).