Impacts of adverse childhood experiences on individuals with autism spectrum disorder

IF 4.8 2区医学 Q1 NEUROSCIENCES

Current Opinion in Neurobiology Pub Date : 2024-11-06 DOI:10.1016/j.conb.2024.102932

Tsutomu Takeda , Manabu Makinodan , Michihiro Toritsuka , Nakao Iwata

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Abstract

Individuals with autism spectrum disorder (ASD) are more likely to experience adverse childhood experiences (ACEs) compared with typically developing (TD) individuals, which predisposes them to an elevated risk of mental health issues. This review elucidates the profound impact of ACEs on individuals with ASD by synthesizing findings from a plethora of epidemiologic and biological studies, encompassing genetics, epigenetics, and neuroimaging. Despite the limited number of studies explicitly focusing on this intersection, the extant literature consistently demonstrates that ASD individuals are disproportionately affected by ACEs, leading to significant deterioration in mental health and brain function. Furthermore, the nature and extent of the effects of ACEs appear to diverge between ASD and TD populations, underscoring the necessity for tailored clinical and research approaches. Understanding these complex and intertwined interactions is imperative for advancing both clinical practice and research, with the goal of mitigating the adverse outcomes associated with ACEs in ASD individuals.

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童年不良经历对自闭症谱系障碍患者的影响

自闭症谱系障碍（ASD）患者与发育正常（TD）的患者相比，更有可能经历不良童年经历（ACE），这使他们出现心理健康问题的风险增加。本综述综合了大量流行病学和生物学研究的结果，包括遗传学、表观遗传学和神经影像学研究，阐明了 ACE 对 ASD 患者的深远影响。尽管明确关注这一交叉点的研究数量有限，但现有文献一致表明，ASD 患者受到 ACE 的影响尤为严重，导致心理健康和大脑功能显著恶化。此外，ACE 影响的性质和程度在 ASD 和 TD 群体中似乎也不尽相同，这突出表明有必要采用量身定制的临床和研究方法。了解这些复杂而又相互交织的相互作用对于推进临床实践和研究都是势在必行的，其目标是减轻与 ASD 患者 ACE 相关的不良后果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Neurobiology 医学-神经科学

CiteScore

11.10

自引率

1.80%

发文量

130

审稿时长

4-8 weeks

期刊介绍： Current Opinion in Neurobiology publishes short annotated reviews by leading experts on recent developments in the field of neurobiology. These experts write short reviews describing recent discoveries in this field (in the past 2-5 years), as well as highlighting select individual papers of particular significance. The journal is thus an important resource allowing researchers and educators to quickly gain an overview and rich understanding of complex and current issues in the field of Neurobiology. The journal takes a unique and valuable approach in focusing each special issue around a topic of scientific and/or societal interest, and then bringing together leading international experts studying that topic, embracing diverse methodologies and perspectives. Journal Content: The journal consists of 6 issues per year, covering 8 recurring topics every other year in the following categories: -Neurobiology of Disease- Neurobiology of Behavior- Cellular Neuroscience- Systems Neuroscience- Developmental Neuroscience- Neurobiology of Learning and Plasticity- Molecular Neuroscience- Computational Neuroscience