Repeated acoustic stimulation (audiogenic kindling) induces estrous arrest in the Wistar audiogenic Rat (WAR) strain. A model of pseudopregnancy?

IF 2.3 3区医学 Q2 BEHAVIORAL SCIENCES

Epilepsy & Behavior Pub Date : 2024-11-06 DOI:10.1016/j.yebeh.2024.110125

Matheus Credendio Eiras , Carolina Gennari Verruma , Artur Fernandes , Ester Silveira Ramos , Cristiana Libardi Miranda Furtado , Norberto Garcia-Cairasco , Rosana Maria dos Reis

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Abstract

Background

Epilepsy is a chronic disorder characterized by a predisposition to epileptic seizures, affecting more than 50 million people worldwide.

Methods

Wistar and Wistar Audiogenic Rats (WAR) females were evaluated regarding estrous cycle and seizures episodes during repeated (kindling) acoustic stimulation at different stages of the estrous cycle.

Results

Acoustic stimulation did not affect the estrous cycle of most Wistar females in either control (91.6 %) or kindled (70.0 %) groups. They also had no seizures episodes. In WAR females, most of the control group (91.6 %) showed regular cycles during acoustic stimulation. In the kindling group, all females showed irregular cycles during acoustic stimulation with diestrus arrest for several days (11.8 ± 1.46 days) and 12 of them (92.3 %) showed, at least, four mesencephalic seizure behaviors during the acoustic stimulation (1 ≤ cSI ≤ 8). In this group, 7 females (53.84 %) also showed limbic seizures (2 ≤ LI ≤ 4). When WAR females were stratified by estrous cycle stage, the group that started the acoustic stimulation during estrus had five females (45.4 %) with diestrus arrest for several days (11.4 ± 0.89 days) and, eight females (72.7 %) exhibited, at least, two seizure behaviors (1 < cSI < 8). When acoustic stimulation was started in the metestrus stage, six females (54.5 %) exhibited diestrus arrest for several days (10.5 ± 3.27 days). In the metestrus group, ten females (90.9 %) presented five or six seizure episodes (1 < cSI < 8).

Conclusion

Our results showed that chronic audiogenic seizures (audiogenic kindling) affect the estrous cycle of WAR females, resulting in a consistent diestrus arrest for 10–12 days, which is consistent with the phenomenon of pseudopregnancy.

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重复声刺激（致听性点燃）诱导 Wistar 致听性大鼠 (WAR) 发情停滞。假孕模型？

背景癫痫是一种慢性疾病，其特点是容易导致癫痫发作，影响着全球 5000 多万人。方法在发情周期的不同阶段，对 Wistar 和 Wistar Audiogenic Rats (WAR) 雌性大鼠进行评估，以了解重复（点燃）声刺激期间的发情周期和癫痫发作情况。它们也没有癫痫发作。在 WAR 雌性动物中，对照组的大多数（91.6%）在声刺激期间表现出规律的发情周期。在点火组中，所有雌性在声刺激期间都表现出不规则的周期，发情停止数天（11.8 ± 1.46 天），其中 12 只（92.3 %）在声刺激期间至少出现四次间脑癫痫发作行为（1 ≤ cSI ≤ 8）。在这一组中，7 名女性（53.84 %）也出现了肢体抽搐（2 ≤ LI ≤ 4）。如果按发情周期阶段对雌性猕猴进行分层，在发情期开始声刺激的组别中有 5 只雌性猕猴（45.4 %）发情停滞数天（11.4 ± 0.89 天），8 只雌性猕猴（72.7 %）至少有两种癫痫发作行为（1 < cSI <8）。在发情期开始进行声刺激时，有六只雌鼠（54.5 %）表现出发情停滞数天（10.5 ± 3.27 天）。结论我们的研究结果表明，慢性听源性癫痫发作（听性点燃）会影响 WAR 雌性动物的发情周期，导致发情持续停止 10-12 天，这与假孕现象一致。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Epilepsy & Behavior 医学-行为科学

CiteScore

5.40

自引率

15.40%

发文量

385

审稿时长

43 days

期刊介绍： Epilepsy & Behavior is the fastest-growing international journal uniquely devoted to the rapid dissemination of the most current information available on the behavioral aspects of seizures and epilepsy. Epilepsy & Behavior presents original peer-reviewed articles based on laboratory and clinical research. Topics are drawn from a variety of fields, including clinical neurology, neurosurgery, neuropsychiatry, neuropsychology, neurophysiology, neuropharmacology, and neuroimaging. From September 2012 Epilepsy & Behavior stopped accepting Case Reports for publication in the journal. From this date authors who submit to Epilepsy & Behavior will be offered a transfer or asked to resubmit their Case Reports to its new sister journal, Epilepsy & Behavior Case Reports.