[EMIM]AlCl4-ionic liquid catalyzed mechanochemically assisted green approach towards the synthesis of quinoxaline, 6H-indolo[2,3-b]quinoxaline and benzimidazole derivatives

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry Pub Date : 2024-11-01 DOI:10.1016/j.rechem.2024.101884

Shafaque M. Shaikh , Gulafshan M. Ansari , Zobia Z. Karbari , Aditi A. Babre , Vikas V. Borge , Vikas M. Bangade , Damodara N. Kommi , Bhushan B. Popatkar

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Abstract

In the presented work, a convenient and effective methodology for the synthesis of quinoxaline, 6H-indolo[2,3-b]quinoxaline and benzimidazole derivatives has been developed. The reaction of 1,2-diamines with various substituted benzil, isatin and aldehydes produces quinoxaline, 6H-indolo[2,3-b]quinoxaline and benzimidazole derivatives respectively. The reaction between 1,2-diamines with various substituted benzils, isatins and aldehydes was carried out in presence of catalytic amount of [EMIM]AlCl₄ (1-ethyl-3-methylimidazolium tetrachloroaluminate) ionic liquid in ethanol under the grinding condition in mortar and pestle. The ease of handling of catalyst, inclusion of eco-friendly solvent, attractive yield of the product, shorter reaction time and overall operational simplicity are some significant outcome of this procedure.

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[EMIM]AlCl4-离子液体催化机械化学辅助合成喹喔啉、6H-吲哚并[2,3-b]喹喔啉和苯并咪唑衍生物的绿色方法

在本研究中，我们开发了一种方便有效的方法来合成喹喔啉、6H-吲哚并[2,3-b]喹喔啉和苯并咪唑衍生物。1,2 二胺与各种取代的苯偶氮、异靛红和醛反应，分别生成喹喔啉、6H-吲哚并[2,3-b]喹喔啉和苯并咪唑衍生物。在乙醇中加入催化剂量的[EMIM]AlCl4（1-乙基-3-甲基咪唑鎓四氯铝酸盐）离子液体后，在研钵和杵的研磨条件下进行了 1,2-二胺与各种取代的苯并、异atin 和醛的反应。催化剂易于处理、使用了环保溶剂、产品收率高、反应时间短以及整体操作简单是该方法的一些重要成果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Results in Chemistry Chemistry-Chemistry (all)

CiteScore

2.70

自引率

8.70%

发文量

380

审稿时长

56 days