Cardio-metabolic Disorders Affected by Genetic Polymorphisms Related to Premature Menopause.

Mohammad Reza Mirinezhad, Hamideh Safarian Bana, Maliheh Aghsizadeh, Mohammad Amin Mohammadi, Hamideh Ghazizadeh, Ali Ebrahimi Dabagh, Sayyedeh Helya Mir Nourbakhsh, Hassan Kiani Shahvandi, Alireza Ghodsi, Mahdie Aghsizadeh, Faezeh Taghipour, Elahe Hasanzadeh, Nazanin Sheikh Andalibi, Hamed Khedmatgozar, Gordon A Ferns, Tayebeh Hamzehloei, Alireza Pasdar, Majid Ghayour-Mobarhan
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Abstract

Background: Premature menopause (PM) is defined as the end of ovulation before the age of 40 years, a condition commonly referred to as primary ovarian insufficiency. It has been shown there is an association between early menopause and a high risk of cardiovascular disease.

Aim: This study aimed to evaluate the effect of genetic polymorphisms related to premature menopause on cardio-metabolic disorders Objective: We aimed to investigate the single nucleotide polymorphisms associated with PM and the risk of cardio-metabolic disorders in the MASHAD cohort study.

Methods: In this cross-sectional study, a total of 117 women with PM were recruited and compared with 183 healthy women. All participants were assessed for anthropometric indices and genotyped for eight selected polymorphisms within seven different genes.

Results: A significant difference was observed in physical activity level (PAL) between the groups. Individuals with rs4806660 CC genotype had a 3.63-fold increased risk of metabolic syndrome. Moreover, individuals with a TT genotype of the rs2303369 polymorphism had a 3.11-- fold increased risk of obesity.

Conclusion: Our findings showed that genetic variations are risk factors related to cardio- metabolic disorders in women with premature menopause.

与过早绝经有关的基因多态性所影响的心血管代谢紊乱。
背景:过早绝经(PM)是指在 40 岁之前结束排卵,这种情况通常被称为原发性卵巢功能不全。目的:本研究旨在评估与过早绝经有关的基因多态性对心血管代谢紊乱的影响:我们的目的是在MASHAD队列研究中调查与更年期提前和心血管代谢疾病风险相关的单核苷酸多态性:在这项横断面研究中,共招募了 117 名患有 PM 的女性,并与 183 名健康女性进行了比较。所有参与者都接受了人体测量指数评估,并对七个不同基因中的八个选定多态性进行了基因分型:结果:观察到各组间的体力活动水平(PAL)存在明显差异。具有 rs4806660 CC 基因型的人患代谢综合征的风险增加了 3.63 倍。此外,rs2303369多态性的TT基因型个体患肥胖症的风险增加了3.11倍:我们的研究结果表明,遗传变异是导致更年期过早妇女心血管代谢紊乱的危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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