Risk factors for cervical lymph node metastasis in oropharyngeal cancer and its impact on prognosis

IF 1.7 4区医学 Q2 OTORHINOLARYNGOLOGY

Brazilian Journal of Otorhinolaryngology Pub Date : 2024-11-05 DOI:10.1016/j.bjorl.2024.101520

Li Zhang , Zhilin Li , Jing Wang , Chen Wang , Shuxin Wen

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引用次数: 0

Abstract

Objective

To understand the characteristics of cervical lymph node metastasis in Oropharyngeal Squamous Cell Carcinoma (OPSCC) patients, explore the risk factors for lymph node metastasis, and its impact on prognosis.

Methods

Retrospective cohort study. Statistical analysis of the relationship between various clinicopathological factors and lymph node involvement, as well as the independent risk factors affecting lymph node metastasis and their impact on prognosis.

Results

The cervical lymph node metastasis rate in this group was 89.2%, with the palatine tonsils and base of the tongue more prone to cervical lymph node metastasis (p = 0.007); lower pathological differentiation of OPSCC was more likely to develop cervical lymph node metastasis (p = 0.017). The P16 protein positive rate in this group was 58.8%. P16 protein expression did not affect the incidence rate of cervical lymph node metastasis in OPSCC (p = 1.000) but influenced the risk of multiple lymph node metastases (p = 0.011) and was a risk factor affecting the prognosis of OPSCC (p = 0.003). However, the lymph node metastasis status did not affect the survival time of OPSCC patients.

Conclusion

In the Shanxi region of China, HPV-related OPSCC accounts for a higher proportion; OPSCC has a high rate of cervical lymph node metastasis, but lymph node metastasis does not significantly increase the mortality risk of OPSCC patients, which may be related to the unique characteristics of HPV-related OPSCC.

Level of Evidence Ⅳ

Retrospective cohort study.

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口咽癌颈淋巴结转移的风险因素及其对预后的影响

目的了解口咽鳞癌（OPSCC）患者颈淋巴结转移的特征，探讨淋巴结转移的风险因素及其对预后的影响：方法：回顾性队列研究。统计分析各种临床病理因素与淋巴结受累的关系，以及影响淋巴结转移的独立危险因素及其对预后的影响：本组患者的颈淋巴结转移率为89.2%，其中腭扁桃体和舌根部更容易发生颈淋巴结转移（P=0.007）；病理分化较低的OPSCC更容易发生颈淋巴结转移（P=0.017）。该组患者的P16蛋白阳性率为58.8%。P16 蛋白表达不影响 OPSCC 的宫颈淋巴结转移发生率（p=1.000），但影响多淋巴结转移的风险（p=0.011），并且是影响 OPSCC 预后的风险因素（p=0.003）。然而，淋巴结转移状态并不影响OPSCC患者的生存时间：结论：在中国山西地区，HPV相关OPSCC所占比例较高；OPSCC的宫颈淋巴结转移率较高，但淋巴结转移并不会显著增加OPSCC患者的死亡风险，这可能与HPV相关OPSCC的特殊性有关。证据级别Ⅳ：回顾性队列研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brazilian Journal of Otorhinolaryngology OTORHINOLARYNGOLOGY-

CiteScore

3.00

自引率

0.00%

发文量

205

审稿时长

4-8 weeks

期刊介绍： Brazilian Journal of Otorhinolaryngology publishes original contributions in otolaryngology and the associated areas (cranio-maxillo-facial surgery and phoniatrics). The aim of this journal is the national and international divulgation of the scientific production interesting to the otolaryngology, as well as the discussion, in editorials, of subjects of scientific, academic and professional relevance. The Brazilian Journal of Otorhinolaryngology is born from the Revista Brasileira de Otorrinolaringologia, of which it is the English version, created and indexed by MEDLINE in 2005. It is the official scientific publication of the Brazilian Association of Otolaryngology and Cervicofacial Surgery. Its abbreviated title is Braz J Otorhinolaryngol., which should be used in bibliographies, footnotes and bibliographical references and strips.