{"title":"Effects of combined exposure of manganese and iron on serum inflammatory factor levels among workers.","authors":"Dian-Yin Liang, Jian-Chao Peng, Bing-Yan Xie, Wen-Xia Qin, Michael Aschner, Shi-Yan Ou, Yue-Ming Jiang","doi":"10.1177/09603271241293112","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The aim of the study is to examine the association between long-term occupational exposure to Mn and Fe and their health effects in workers.</p><p><strong>Methods: </strong>108 Mn workers were selected for the Mn exposure groups; 92 non-Mn workers were in the control group. Inductively coupled plasma-mass spectrometry was used to determine the Mn and Fe concentration in the working environment. Graphite furnace-atomic absorption spectroscopy was used to determine the blood Mn concentration of workers. Serum inflammatory factors were measured by enzyme-linked immunosorbent assay.</p><p><strong>Results: </strong>The blood Mn concentration, positive rate of clinical symptoms and serum inflammatory response in the Mn exposure group was higher than in the control group.</p><p><strong>Conclusions: </strong>Low levels of Mn exposure may increase blood Mn concentrations, the rate of complaints of neurological symptoms and promote increased serum inflammatory response in workers.</p>","PeriodicalId":94029,"journal":{"name":"Human & experimental toxicology","volume":"43 ","pages":"9603271241293112"},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Human & experimental toxicology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/09603271241293112","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: The aim of the study is to examine the association between long-term occupational exposure to Mn and Fe and their health effects in workers.
Methods: 108 Mn workers were selected for the Mn exposure groups; 92 non-Mn workers were in the control group. Inductively coupled plasma-mass spectrometry was used to determine the Mn and Fe concentration in the working environment. Graphite furnace-atomic absorption spectroscopy was used to determine the blood Mn concentration of workers. Serum inflammatory factors were measured by enzyme-linked immunosorbent assay.
Results: The blood Mn concentration, positive rate of clinical symptoms and serum inflammatory response in the Mn exposure group was higher than in the control group.
Conclusions: Low levels of Mn exposure may increase blood Mn concentrations, the rate of complaints of neurological symptoms and promote increased serum inflammatory response in workers.
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