Immunoproteomics: A Review of Techniques, Applications, and Advancements.

IF 1 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Protein and Peptide Letters Pub Date : 2024-01-01 DOI:10.2174/0109298665333029240926092919

Virendra S Gomase, Suchita P Dhamane, Pavan G Kakade

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引用次数: 0

Abstract

Immunoproteomics is the branch of proteomics with an emphasis on the study of functional peptides and proteins related to the immune system. Combining proteomics techniques with immunological research aims to uncover the complex interactions of proteins involved in immune responses. This review discusses the methods, applications, and recent advancements in immunoproteomics, highlighting its critical role in understanding immune responses, discovering biomarkers, and developing vaccines and therapeutics. This study offers a comprehensive exploration of the methodologies, applications, and advancements within immunoproteomics. Techniques such as mass spectrometry, antibody-based assays, and computational analysis are pivotal in unraveling the complexities of the immune system at the protein level. Immunoproteomics finds diverse applications in biomarker discovery, vaccine development, autoimmune disease research, infectious disease diagnostics, and cancer immunotherapy. Challenges, including data integration, sample heterogeneity, and biomarker validation, persist, necessitating innovative approaches and interdisciplinary collaborations. In the future, immunoproteomics will likely play a major role in expanding our knowledge of immune-related diseases and accelerating the creation of targeted and precise immunotherapies.

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免疫蛋白组学：技术、应用和进展综述》。

免疫蛋白质组学是蛋白质组学的一个分支，重点研究与免疫系统有关的功能肽和蛋白质。将蛋白质组学技术与免疫学研究相结合，旨在揭示参与免疫反应的蛋白质之间复杂的相互作用。这篇综述讨论了免疫蛋白组学的方法、应用和最新进展，强调了免疫蛋白组学在了解免疫反应、发现生物标记物以及开发疫苗和疗法方面的关键作用。本研究全面探讨了免疫蛋白组学的方法、应用和进展。质谱分析、抗体检测和计算分析等技术对于从蛋白质层面揭示免疫系统的复杂性至关重要。免疫蛋白质组学在生物标记物发现、疫苗开发、自身免疫性疾病研究、传染病诊断和癌症免疫疗法中有着广泛的应用。数据整合、样本异质性和生物标记物验证等挑战依然存在，需要创新方法和跨学科合作。未来，免疫蛋白组学可能会在扩大我们对免疫相关疾病的了解和加速创造有针对性的精确免疫疗法方面发挥重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Protein and Peptide Letters 生物-生化与分子生物学

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

2 months

期刊介绍： Protein & Peptide Letters publishes letters, original research papers, mini-reviews and guest edited issues in all important aspects of protein and peptide research, including structural studies, advances in recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, and drug design. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallization and preliminary structure determination of biologically important proteins are considered only if they include significant new approaches or deal with proteins of immediate importance, and preliminary structure determinations of biologically important proteins. Purely theoretical/review papers should provide new insight into the principles of protein/peptide structure and function. Manuscripts describing computational work should include some experimental data to provide confirmation of the results of calculations. Protein & Peptide Letters focuses on: Structure Studies Advances in Recombinant Expression Drug Design Chemical Synthesis Function Pharmacology Enzymology Conformational Analysis Immunology Biotechnology Protein Engineering Protein Folding Sequencing Molecular Recognition Purification and Analysis