Cardiovascular Autonomic Dysfunction Before and After Chemotherapy in Cancer Patients.

IF 2.9 3区 医学 Q2 CLINICAL NEUROLOGY
So Young Yoon, Jeeyoung Oh
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引用次数: 0

Abstract

Complications that occur during cancer therapy have emerged as a major contributor to the poor quality of life experienced by cancer patients as they live longer due to improved treatments. Many studies have investigated chemotherapy-induced peripheral neuropathy, but few have investigated the autonomic nervous system. Cardiovascular autonomic dysfunction (CAD) contributes to the distressing symptoms experienced by cancer patients, and it is also related to poor treatment outcomes. CAD has a multifactorial etiology in patients with cancer: it can be caused by the cancer itself, chemotherapy or radiation therapy, or other comorbidities. Its symptoms are nonspecific, and they include orthostatic hypotension, resting tachycardia, dizziness, chest tightness, and exertional dyspnea. It is important to suspect CAD and perform therapeutic interventions in a clinical context, because a patient who is more frail is less like to endure the treatment process. The quality of life of patients receiving active cancer treatments can be improved by evaluating the risk of CAD before and after chemotherapy, and combining both nonpharmacological and pharmacological management. Here we review the prevalence, pathogenesis, diagnosis, and treatment of CAD, which is the most common and a sometimes serious symptom in cancer patients.

癌症患者化疗前后的心血管自主神经功能障碍
随着治疗方法的改进,癌症患者的寿命越来越长,癌症治疗过程中出现的并发症已成为导致癌症患者生活质量低下的主要原因。许多研究对化疗引起的周围神经病变进行了调查,但很少有研究对自律神经系统进行调查。心血管自主神经功能障碍(CAD)是导致癌症患者出现痛苦症状的原因之一,同时也与治疗效果不佳有关。癌症患者心血管自律神经失调的病因是多方面的:癌症本身、化疗或放疗或其他合并症都可能导致心血管自律神经失调。其症状无特异性,包括直立性低血压、静息性心动过速、头晕、胸闷和劳力性呼吸困难。在临床上,怀疑患有 CAD 并进行治疗干预是非常重要的,因为体质较弱的患者更不愿意忍受治疗过程。通过在化疗前后评估患 CAD 的风险,并结合非药物治疗和药物治疗,可以提高接受积极癌症治疗的患者的生活质量。CAD是癌症患者最常见的症状,有时也是最严重的症状,我们在此回顾CAD的发病率、发病机制、诊断和治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Clinical Neurology
Journal of Clinical Neurology 医学-临床神经学
CiteScore
4.50
自引率
6.50%
发文量
0
审稿时长
>12 weeks
期刊介绍: The JCN aims to publish the cutting-edge research from around the world. The JCN covers clinical and translational research for physicians and researchers in the field of neurology. Encompassing the entire neurological diseases, our main focus is on the common disorders including stroke, epilepsy, Parkinson''s disease, dementia, multiple sclerosis, headache, and peripheral neuropathy. Any authors affiliated with an accredited biomedical institution may submit manuscripts of original articles, review articles, and letters to the editor. The JCN will allow clinical neurologists to enrich their knowledge of patient management, education, and clinical or experimental research, and hence their professionalism.
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