Non-pharmaceutical interventions to reduce influenza transmission in households: a systematic review and meta-analysis

IF 4.8 2区医学 Q1 INFECTIOUS DISEASES

International Journal of Infectious Diseases Pub Date : 2024-11-04 DOI:10.1016/j.ijid.2024.107291

Jessica Y. Wong , Wey Wen Lim , Justin K. Cheung , Caitriona Murphy , Eunice Y.C. Shiu , Jingyi Xiao , Dongxuan Chen , Yanmin Xie , Mingwei Li , Hualei Xin , Michelle Szeto , Sammi Choi , Benjamin J. Cowling

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引用次数: 0

Abstract

Background

Influenza pandemic plans often recommend non-pharmaceutical interventions (NPIs) in household settings, including hand hygiene and face masks. We reviewed evidence supporting the recommendations of these measures to prevent the spread of influenza in households.

Methods

We performed systematic reviews between 26 May and 30 August 2022 in Medline, PubMed, EMBASE, and CENTRAL to identify evidence for the effectiveness of selected measures recommended by representative national influenza pandemic plans. We prioritized evidence from randomized controlled trials conducted during influenza pandemics and seasonal influenza epidemics. Fixed-effects models were used to estimate the overall effects. Systematic reviews were registered in the OSF registry (https://osf.io/8kyth).

Results

We selected 9 NPIs for evidence review. We identified 9 randomized controlled trials related to hand hygiene and face masks in household settings. 2 studies reported that measures could delay the introduction of influenza virus infections into households. However, we did not identify evidence from randomized controlled trials that indicated a substantial effect of hand hygiene and face masks in preventing the spread of influenza within households.

Conclusion

Limited evidence indicated that within-household measures may likely be effective only when implemented before or as soon as possible after symptom onset in an infected case. Improving the evidence base for NPIs in households and elsewhere is a continuing priority.

Funding

World Health Organization and the Strategic Topic Grants Scheme.

查看原文本刊更多论文

减少流感在家庭中传播的非药物干预措施：系统回顾和荟萃分析。

背景：流感大流行计划通常建议在家庭环境中采取非药物干预措施（NPI），包括手部卫生和口罩。我们回顾了支持这些措施建议的证据，以防止流感在家庭中传播：我们于 2022 年 5 月 26 日至 8 月 30 日期间在 Medline、PubMed、EMBASE 和 CENTRAL 中进行了系统性回顾，以确定具有代表性的国家流感大流行计划所推荐的选定措施的有效性证据。我们优先考虑了在流感大流行和季节性流感流行期间进行的随机对照试验的证据。我们使用固定效应模型来估算总体效果。系统综述在 OSF 注册表（https://osf.io/8kyth）中注册：我们选择了 9 项 NPI 进行证据审查。我们确定了 9 项与家庭环境中的手部卫生和口罩有关的随机对照试验。2 项研究报告称，这些措施可延缓流感病毒感染进入家庭。但是，我们没有从随机对照试验中找到证据表明手部卫生和口罩对预防流感在家庭内传播有实质性作用：有限的证据表明，只有在感染病例出现症状之前或之后尽快实施家庭内部措施，才可能有效。改进家庭内和其他地方的非传染性措施的证据基础仍是当务之急：资金来源：世界卫生组织和战略专题资助计划。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Infectious Diseases 医学-传染病学

CiteScore

18.90

自引率

2.40%

发文量

1020

审稿时长

30 days

期刊介绍： International Journal of Infectious Diseases (IJID) Publisher: International Society for Infectious Diseases Publication Frequency: Monthly Type: Peer-reviewed, Open Access Scope: Publishes original clinical and laboratory-based research. Reports clinical trials, reviews, and some case reports. Focuses on epidemiology, clinical diagnosis, treatment, and control of infectious diseases. Emphasizes diseases common in under-resourced countries.