Master regulators of neurogenesis: the dynamic roles of Ephrin receptors across diverse cellular niches.

IF 5.8 1区医学 Q1 PSYCHIATRY

Translational Psychiatry Pub Date : 2024-11-06 DOI:10.1038/s41398-024-03168-4

Dilan Rasool, Arezu Jahani-Asl

引用次数: 0

Abstract

The ephrin receptors (EphRs) are the largest family of receptor tyrosine kinases (RTKs) that are abundantly expressed in the developing brain and play important roles at different stages of neurogenesis ranging from neural stem cell (NSC) fate specification to neural migration, morphogenesis, and circuit assembly. Defects in EphR signalling have been associated with several pathologies including neurodevelopmental disorders (NDDs), intellectual disability (ID), and neurodegenerative diseases (NDs). Here, we review our current understanding of the complex and dynamic role of EphRs in the brain and discuss how deregulation of these receptors contributes to disease, highlighting their potential as valuable druggable targets.

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神经发生的主调节器：Ephrin受体在不同细胞龛中的动态作用。

ephrin受体（EphRs）是最大的受体酪氨酸激酶（RTKs）家族，在发育中的大脑中大量表达，并在神经发生的不同阶段发挥重要作用，从神经干细胞（NSC）的命运规范到神经迁移、形态发生和电路组装。EphR 信号的缺陷与多种病症有关，包括神经发育障碍（NDD）、智力障碍（ID）和神经退行性疾病（ND）。在此，我们回顾了我们目前对 EphRs 在大脑中复杂而动态的作用的理解，并讨论了这些受体的失调是如何导致疾病的，同时强调了它们作为有价值的药物靶点的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Translational Psychiatry PSYCHIATRY-

CiteScore

11.50

自引率

2.90%

发文量

484

审稿时长

23 weeks

期刊介绍： Psychiatry has suffered tremendously by the limited translational pipeline. Nobel laureate Julius Axelrod''s discovery in 1961 of monoamine reuptake by pre-synaptic neurons still forms the basis of contemporary antidepressant treatment. There is a grievous gap between the explosion of knowledge in neuroscience and conceptually novel treatments for our patients. Translational Psychiatry bridges this gap by fostering and highlighting the pathway from discovery to clinical applications, healthcare and global health. We view translation broadly as the full spectrum of work that marks the pathway from discovery to global health, inclusive. The steps of translation that are within the scope of Translational Psychiatry include (i) fundamental discovery, (ii) bench to bedside, (iii) bedside to clinical applications (clinical trials), (iv) translation to policy and health care guidelines, (v) assessment of health policy and usage, and (vi) global health. All areas of medical research, including — but not restricted to — molecular biology, genetics, pharmacology, imaging and epidemiology are welcome as they contribute to enhance the field of translational psychiatry.