[Gluteal tendinitis and primary coxarthrosis may lead to iliotibial band syndrome: a Mendelian randomization study].

Q3 Medicine

南方医科大学学报杂志 Pub Date : 2024-09-20 DOI:10.12122/j.issn.1673-4254.2024.09.23

C Yao, W Li, R Pang, J Zhou

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Abstract

Objective: To analyze the causal relationship of gluteal tendinitis and primary coxarthrosis with the occurrence of iliotibial band syndrome using Mendelian randomization.

Methods: The GWAS data of gluteal tendinitis, primary coxarthrosis and iliotibial band syndrome were screened for high correlation single-nucleotide polymorphisms (SNPs). Mendelian randomization analysis was performed using random-effects inverse variance weighting (IVW), MR-Egger regression, and weighted median method to determine whether gluteal tendinitis and primary coxarthrosis were causally related with iliotibial band syndrome. Heterogeneity test, multiple validity test and sensitivity analysis, and clinical data analysis were used to verify the reliability of the results.

Results: Both gluteal tendinitis [IVW: OR(95% CI)=1.32 (1.03-1.68), P=0.026] and primary coxarthrosis [IVW: OR (95% CI)=1.40 (1.06-1.84), P=0.017] was positively correlated with iliotibial band syndrome.

Conclusion: Gluteal tendinitis and primary coxarthrosis may increase the risk of iliotibial band syndrome.

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[臀部肌腱炎和原发性髋关节炎可能导致髂胫束综合征：孟德尔随机研究]。

目的采用孟德尔随机法分析臀部腱鞘炎和原发性髋关节病与髂胫束综合征发生的因果关系：对臀肌腱炎、原发性髋关节病和髂胫束综合征的 GWAS 数据进行筛选，寻找高相关性的单核苷酸多态性（SNPs）。采用随机效应反方差加权法（IVW）、MR-Egger 回归法和加权中位数法进行孟德尔随机分析，以确定臀部肌腱炎和原发性髋关节病是否与髂胫束综合征存在因果关系。为验证结果的可靠性，采用了异质性检验、多重有效性检验和敏感性分析以及临床数据分析：结果：臀肌腱炎[IVW：OR（95% CI）=1.32（1.03-1.68），P=0.026]和原发性髋关节病[IVW：OR（95% CI）=1.40（1.06-1.84），P=0.017]均与髂胫束综合征呈正相关：结论：臀肌腱炎和原发性髋关节病可能会增加髂胫束综合征的风险。

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