Repeatability of quantitative MR fingerprinting for T₁ and T₂ measurements of metastatic bone in prostate cancer patients.

IF 4.7 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

European Radiology Pub Date : 2024-11-06 DOI:10.1007/s00330-024-11162-z

Mihaela Rata, Matthew R Orton, Nina Tunariu, Andra Curcean, Julie Hughes, Erica Scurr, Matthew Blackledge, James d'Arcy, Yun Jiang, Vikas Gulani, Dow-Mu Koh

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引用次数: 0

Abstract

Objectives: MR fingerprinting (MRF) has the potential to quantify treatment response. This study evaluated the repeatability of MRF-derived T₁ and T₂ relaxation times in bone metastasis, bone, and muscle in patients with metastatic prostate cancer.

Materials and methods: This prospective single-centre study included same-day repeated MRF acquisitions from 20 patients (August 2019-October 2020). Phantom and human data were acquired on a 1.5-T MR scanner using a research MRF sequence outputting T₁ and T₂ maps. Regions of interest (ROIs) across three tissue types (bone metastasis, bone, muscle) were drawn on two separate acquisitions. Repeatability of T₁ and T₂ was assessed using Bland-Altman plots, together with repeatability (r) and intraclass correlation (ICC) coefficients. Mean T₁ and T₂ were reported per tissue type.

Results: Twenty patients with metastatic prostate cancer (mean age, 70 years ± 8 (standard deviation)) were evaluated and bone metastasis (n = 44), normal-appearing bone (n = 14), and muscle (n = 20) ROIs were delineated. Relative repeatability of T₁ measurements was 6.9% (bone metastasis), 32.6% (bone), 5.8% (muscle) and 21.8%, 32.2%, 16.1% for T₂ measurements. The ICC of T₁ was 0.97 (bone metastasis), 0.94 (bone), 0.96 (muscle); ICC of T₂ was 0.94 (bone metastasis), 0.94 (bone), 0.91 (muscle). T₁ values in bone metastasis were higher than in bone (p < 0.001). T₂ values showed no difference between bone metastasis and bone (p = 0.5), but could separate active versus treated metastasis (p < 0.001).

Conclusion: MRF allows repeatable T₁ and T₂ measurements in bone metastasis, bone, and muscle in patients with primary prostate cancer. Such measurements may help quantify the treatment response of bone metastasis.

Key points: Question MR fingerprinting has the potential to characterise bone metastasis and its response to treatment. Findings Repeatability of MRF-based T₁ measurements in bone metastasis and muscle was better than for T₂. Clinical relevance MR fingerprinting allows repeatable T₁ and T₂ quantitative measurements in bone metastasis, bone, and muscle in patients with primary prostate cancer, which makes it potentially applicable for disease characterisation and assessment of treatment response.

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用于前列腺癌患者转移性骨质 T1 和 T2 测量的定量 MR 指纹测量的重复性。

目的：磁共振指纹图谱（MRF）具有量化治疗反应的潜力。本研究评估了转移性前列腺癌患者骨转移灶、骨骼和肌肉中MRF衍生的T1和T2弛豫时间的可重复性：这项前瞻性单中心研究包括对20名患者（2019年8月至2020年10月）进行的当天重复MRF采集。在 1.5-T 磁共振扫描仪上使用研究型 MRF 序列输出 T1 和 T2 地图，采集模型和人体数据。在两次独立采集中绘制了三种组织类型（骨转移瘤、骨、肌肉）的感兴趣区（ROI）。使用布兰-阿尔特曼图以及重复性（r）和类内相关（ICC）系数评估 T1 和 T2 的重复性。报告了每种组织类型的 T1 和 T2 平均值：对 20 名转移性前列腺癌患者（平均年龄为 70 岁 ± 8（标准差））进行了评估，并划分了骨转移灶（44 个）、正常外观骨（14 个）和肌肉（20 个）ROI。T1 测量的相对重复性分别为 6.9%（骨转移瘤）、32.6%（骨骼）、5.8%（肌肉），T2 测量的相对重复性分别为 21.8%、32.2%、16.1%。T1 的 ICC 为 0.97（骨转移）、0.94（骨）、0.96（肌肉）；T2 的 ICC 为 0.94（骨转移）、0.94（骨）、0.91（肌肉）。骨转移瘤的 T1 值高于骨（p 2 值显示骨转移瘤与骨之间无差异（p = 0.5），但可区分活动性转移瘤和治疗性转移瘤（p 结论：MRF 可重复 T1 和 T2 值，并可显示骨转移瘤和骨之间的差异（p = 0.5）：MRF 可对原发性前列腺癌患者的骨转移灶、骨和肌肉进行可重复的 T1 和 T2 测量。这些测量结果有助于量化骨转移灶的治疗反应：问题核磁共振指纹图谱有可能描述骨转移及其对治疗的反应。研究结果基于 MRF 的骨转移和肌肉 T1 测量的重复性优于 T2 测量。临床意义 MR指纹图谱可对原发性前列腺癌患者的骨转移灶、骨骼和肌肉进行可重复的T1和T2定量测量，因此有可能用于疾病特征描述和治疗反应评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Radiology 医学-核医学

CiteScore

11.60

自引率

8.50%

发文量

874

审稿时长

2-4 weeks

期刊介绍： European Radiology (ER) continuously updates scientific knowledge in radiology by publication of strong original articles and state-of-the-art reviews written by leading radiologists. A well balanced combination of review articles, original papers, short communications from European radiological congresses and information on society matters makes ER an indispensable source for current information in this field. This is the Journal of the European Society of Radiology, and the official journal of a number of societies. From 2004-2008 supplements to European Radiology were published under its companion, European Radiology Supplements, ISSN 1613-3749.