Prognostic value of neutrophil to lymphocyte ratio for patients with bladder cancer undergoing radical cystectomy: a systematic review and meta-analysis.

IF 3.5 3区医学 Q2 ONCOLOGY

Frontiers in Oncology Pub Date : 2024-10-24 eCollection Date: 2024-01-01 DOI:10.3389/fonc.2024.1463173

Zhan Chen, Yao Zhang, Telei Chen

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引用次数: 0

Abstract

Objectives: This study evaluated the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) for survival outcomes in bladder cancer patients treated with radical cystectomy.

Methods: Studies assessing NLR's prognostic significance for bladder cancer after radical cystectomy were identified from PubMed, Embase, Web of Science, and Cochrane databases until April 2024. Survival outcomes analyzed included overall survival (OS), disease-free survival (DFS), relapse-free survival (RFS), cancer-specific survival (CSS), and progression-free survival (PFS).

Results: The meta-analysis comprised 15 cohort studies with 8,448 patients. Multivariate analysis showed significantly shorter OS, CSS, DFS, and RFS in the high NLR group compared to the low NLR group. However, no significant difference in PFS was observed between the groups.

Conclusions: NLR serves as an independent prognostic indicator for bladder cancer patients undergoing radical cystectomy, with elevated NLR associated with poorer survival. Further large-scale, prospective studies are warranted to validate the relationship between NLR and prognosis in bladder cancer.

Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024549573.

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接受根治性膀胱切除术的膀胱癌患者中性粒细胞与淋巴细胞比值的预后价值：系统综述与荟萃分析。

研究目的本研究评估了中性粒细胞与淋巴细胞比值（NLR）对接受根治性膀胱切除术治疗的膀胱癌患者生存预后的价值：从PubMed、Embase、Web of Science和Cochrane数据库中筛选出评估NLR对根治性膀胱切除术后膀胱癌预后意义的研究，直至2024年4月。分析的生存结果包括总生存期（OS）、无病生存期（DFS）、无复发生存期（RFS）、癌症特异性生存期（CSS）和无进展生存期（PFS）：荟萃分析包括 15 项队列研究，共有 8448 名患者参与。多变量分析显示，与低 NLR 组相比，高 NLR 组的 OS、CSS、DFS 和 RFS 明显较短。结论：NLR是一种独立的预后指标：结论：NLR 是接受根治性膀胱切除术的膀胱癌患者的独立预后指标，NLR 升高与生存率降低有关。有必要进一步开展大规模前瞻性研究，以验证NLR与膀胱癌预后之间的关系。系统综述注册：https://www.crd.york.ac.uk/PROSPERO/，标识符为CRD42024549573。

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来源期刊

Frontiers in Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

6.20

自引率

10.60%

发文量

6641

审稿时长

14 weeks

期刊介绍： Cancer Imaging and Diagnosis is dedicated to the publication of results from clinical and research studies applied to cancer diagnosis and treatment. The section aims to publish studies from the entire field of cancer imaging: results from routine use of clinical imaging in both radiology and nuclear medicine, results from clinical trials, experimental molecular imaging in humans and small animals, research on new contrast agents in CT, MRI, ultrasound, publication of new technical applications and processing algorithms to improve the standardization of quantitative imaging and image guided interventions for the diagnosis and treatment of cancer.