WHO/INRUD prescribing indicators with a focus on antibiotics utilization patterns at outpatient department of Adigrat general hospital, Tigrai, Ethiopia: a retrospective cross-sectional study.

IF 4.8 2区 医学 Q1 INFECTIOUS DISEASES
Gebretekle Gebremichael Hailesilase, Brhane Gebrehiwot Welegebrial, Mezgebe Gidey Weres, Senait Abera Gebrewahd
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引用次数: 0

Abstract

Background: The World Health Organization (WHO) defines rational use of drug as a state in which medications are received by patients appropriately according to their clinical needs and individual requirement, for adequate period and at the right cost. More than 50% of all medicines are prescribed, dispensed, or sold inappropriately worldwide. This study aimed to evaluate the prescribing patterns in Adigrat general hospital, Tigrai, Ethiopia.

Methods: A retrospective cross-sectional study was done to evaluate prescription patterns. A systematic random sampling technique was used to select 600 prescriptions and the prescriptions were reviewed using WHO/International Network of Rational Use of Drugs prescribing indicators. Data was collected from prescriptions dispensed from 01 March 2023 to 30 March 2024 at outpatient pharmacy of Adigrat general hospital. Data was analyzed using SPSS version 21 and a p-value < 0.05 was declared statistically significant.

Results: A total of 1088 medicines were prescribed in 600 prescription encounters, giving an average number of 1.8 (± 0.83) medicines per encounter. The percentage of medicines prescribed by generic name was 91.5% while 98.7% of the medicines were prescribed from essential medicine list (EML). Besides, the percentages of encounters containing at least one antibiotic and one injection were 44.5% and 7.2%, respectively. A total of 340 antibiotics were prescribed in 267 encounters. Penicillins (34.4%), macrolides (23.8%) and fluoroquinolones (17.1%) were the most prevalent antibiotics classes. The "Access" and "Watch" groups covered 54.4% and 45.6% of the total antibiotics prescribed, respectively. Being under 18 years old [Adjusted Odds Ratio (AOR): 9.830, CI: 4.062-23.786], being prescribed with three medicines (AOR: 3.247, CI: 1.571-6.708) and certain diagnosis like diseases of the respiratory system (AOR: 3.750, CI: 2.136-6.584) were significantly associated with antibiotic prescribing.

Conclusion: This study showed deviations of prescribing patterns from WHO standards. The percentage of prescriptions with antibiotic was far from WHO optimal value. The use of antibiotics from "Access" group was below WHO standard. The percentage of medicines prescribed by generic name and the percentage of encounters with injection also deviated from WHO standard. Antibiotics prescribing showed significantly association with age, number of medicines and certain diseases.

埃塞俄比亚提格雷省阿迪格拉特综合医院门诊部抗生素使用模式的世卫组织/INRUD处方指标:一项回顾性横断面研究。
背景:世界卫生组织(WHO)对合理用药的定义是:患者根据自己的临床需要和个人要求,在适当的时间内,以适当的价格获得适当的药物。在全球范围内,50% 以上的药物被不当处方、配发或销售。本研究旨在评估埃塞俄比亚提格雷省阿迪格拉特综合医院的处方模式:方法:采用回顾性横断面研究来评估处方模式。采用系统随机抽样技术抽取了 600 份处方,并使用世界卫生组织/国际合理用药网络的处方指标对处方进行了审查。数据收集自 2023 年 3 月 1 日至 2024 年 3 月 30 日在阿迪格拉特综合医院门诊药房开具的处方。数据分析采用 SPSS 21 版和 P 值:600 次处方共开出 1088 种药品,平均每次开出 1.8 (± 0.83) 种药品。按通用名处方的药品占 91.5%,而 98.7%的药品来自基本药物目录(EML)。此外,至少含有一种抗生素和一种注射剂的病例比例分别为 44.5%和 7.2%。在 267 次就诊中,共开出了 340 种抗生素处方。青霉素类(34.4%)、大环内酯类(23.8%)和氟喹诺酮类(17.1%)是最常用的抗生素类别。使用 "组和 "观察 "组分别占抗生素处方总量的 54.4% 和 45.6%。18 岁以下[调整比值比(AOR):9.830,CI:4.062-23.786]、处方三种药物(AOR:3.247,CI:1.571-6.708)和某些诊断(如呼吸系统疾病)(AOR:3.750,CI:2.136-6.584)与抗生素处方显著相关:本研究表明,处方模式与世界卫生组织的标准存在偏差。使用抗生素的处方比例与世界卫生组织的最佳值相去甚远。无障碍 "组抗生素的使用低于世卫组织标准。使用通用名开具处方的比例和使用注射剂开具处方的比例也偏离了世界卫生组织的标准。抗生素处方与年龄、用药次数和某些疾病有明显关联。
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来源期刊
Antimicrobial Resistance and Infection Control
Antimicrobial Resistance and Infection Control PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH -INFECTIOUS DISEASES
CiteScore
9.70
自引率
3.60%
发文量
140
审稿时长
13 weeks
期刊介绍: Antimicrobial Resistance and Infection Control is a global forum for all those working on the prevention, diagnostic and treatment of health-care associated infections and antimicrobial resistance development in all health-care settings. The journal covers a broad spectrum of preeminent practices and best available data to the top interventional and translational research, and innovative developments in the field of infection control.
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