Aura and osmophobia are associated with the IL1A -889C > T (rs1800587) variant in migraine.

IF 1 4区医学 Q4 NEUROSCIENCES

Arquivos de neuro-psiquiatria Pub Date : 2024-10-01 Epub Date: 2024-11-06 DOI:10.1055/s-0044-1791200

Amanda Brant Rocha, Giovana Ortiz Zendrini, Maria Paula Bertoletti Juliani, Regina Célia Poli Frederico, Valéria Aparecida Bello, Carlos Eduardo Coral de Oliveira, Edna Maria Vissoci Reiche, Aline Vitali-Silva

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引用次数: 0

Abstract

Background: Migraine belongs to the group of primary headaches, affecting 14.4% of the global population. The pathophysiological mechanisms of migraine involve the interplay between hypothalamic activation, cortical spreading depression, trigeminal stimulation, and inflammatory components with neurogenic inflammation or neuroinflammation.

Objective: To assess the frequency of the IL1A -899C > T (rs1800587) genetic variant in patients with migraine and healthy controls, as well as its association with the clinical manifestations of migraine.

Methods: We conducted a case-control study involving 92 migraine patients and 88 healthy controls matched for age, sex, body mass index (BMI), and ethnicity. Demographic, anthropometric, and clinical data were obtained. The IL1A -889C > T (rs1800587) variant was identified using real-time polymerase chain reaction.

Results: The study comprised predominantly women and Caucasian individuals, with no significant differences in terms of age, sex, ethnicity, or BMI observed between the migraine and control groups. Within the migraine group, 57.6% had episodic migraines, and 45.7% experienced aura. The patients carrying the CT genotype showed stronger associations with the presence of aura (CT: 57.7%; TT: 27.5%; p = 0.027), and those carrying the CT and TT genotypes showed higher osmophobia rates when compared with the CC genotype (p = 0.003). The IL1A -889C > T genetic variant was not associated with migraine susceptibility, be it chronic or episodic, nor to other symptoms associated with migraine.

Conclusion: The IL1A -889C > T genetic variant was associated with aura and osmophobia in migraine patients.

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偏头痛患者的先兆和恐水症与 IL1A -889C > T (rs1800587) 变异有关。

背景：偏头痛属于原发性头痛，占全球总人口的 14.4%。偏头痛的病理生理机制涉及下丘脑激活、皮层扩散抑制、三叉神经刺激以及神经源性炎症或神经炎症的炎症成分之间的相互作用：评估偏头痛患者和健康对照组中 IL1A -899C > T（rs1800587）基因变异的频率及其与偏头痛临床表现的关联：我们进行了一项病例对照研究，涉及 92 名偏头痛患者和 88 名健康对照者，他们的年龄、性别、体重指数（BMI）和种族均匹配。我们获得了人口统计学、人体测量学和临床数据。使用实时聚合酶链反应鉴定了 IL1A -889C > T（rs1800587）变异：研究对象主要为女性和白种人，偏头痛组和对照组在年龄、性别、种族或体重指数方面无明显差异。在偏头痛组中，57.6%的人有发作性偏头痛，45.7%的人有先兆。携带 CT 基因型的患者与先兆的出现有更强的关联（CT：57.7%；TT：27.5%；p = 0.027），与 CC 基因型相比，携带 CT 和 TT 基因型的患者有更高的恐水症发病率（p = 0.003）。IL1A -889C > T基因变异与偏头痛的易感性（无论是慢性还是发作性）无关，也与偏头痛的其他相关症状无关：结论：IL1A -889C > T基因变异与偏头痛患者的先兆和恐水症有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Arquivos de neuro-psiquiatria 医学-精神病学

CiteScore

2.10

自引率

7.10%

发文量

262

审稿时长

4-8 weeks

期刊介绍： Arquivos de Neuro-Psiquiatria is the official journal of the Brazilian Academy of Neurology. The mission of the journal is to provide neurologists, specialists and researchers in Neurology and related fields with open access to original articles (clinical and translational research), editorials, reviews, historical papers, neuroimages and letters about published manuscripts. It also publishes the consensus and guidelines on Neurology, as well as educational and scientific material from the different scientific departments of the Brazilian Academy of Neurology. The ultimate goals of the journal are to contribute to advance knowledge in the areas of Neurology and Neuroscience, and to provide valuable material for training and continuing education for neurologists and other health professionals working in the area. These goals might contribute to improving care for patients with neurological diseases. We aim to be the best Neuroscience journal in Latin America within the peer review system.