Global trends and projections of occupational trichloroethylene (TCE) exposure-associated kidney cancer: Insights of the Global Burden of Disease (GBD) Study 2021 from 1990 to 2021 and prediction to 2050

IF 6.2 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Ecotoxicology and Environmental Safety Pub Date : 2024-11-06 DOI:10.1016/j.ecoenv.2024.117252

Hang Huang , Ping Li , Haoran Jiang , Junkai Hong , Yongyong Lu

{"title":"Global trends and projections of occupational trichloroethylene (TCE) exposure-associated kidney cancer: Insights of the Global Burden of Disease (GBD) Study 2021 from 1990 to 2021 and prediction to 2050","authors":"Hang Huang , Ping Li , Haoran Jiang , Junkai Hong , Yongyong Lu","doi":"10.1016/j.ecoenv.2024.117252","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Exposure to trichloroethylene (TCE) in occupations is associated with an increased risk of kidney cancer (KC). However, there is a lack of comprehensive study on the global burden of occupational exposure to TCE-related KC.</div></div><div><h3>Methods</h3><div>Epidemiological data on occupational TCE exposure-associated KC from 1990 to 2021 were obtained from Global Burden of Disease (GBD) 2021 study, including death counts and disability-adjusted life years (DALYs). Global burden of this disease was stratified by genders, age, socio-demographic index (SDI) quintiles, GBD subcontinental regions, and countries. The estimated annual percentage change (EAPC) was calculated to illustrate trends over the last 32 years, and forecasts were conducted to predict the disease burden until 2050.</div></div><div><h3>Results</h3><div>In 2021, the global age-standardized death rate (ASDR) of occupational TCE exposure-related KC was 0.0009 (95 %UI: 0.0002–0.0016) per 100,000 persons, and the age-standardized DALY rate (ASDAR) was 0.0284 (95 %UI: 0.0062–0.0522) per 100,000 individuals. The disease showed significant heterogeneity by sex and age, with males bearing a notably higher burden, and the burden being concentrated in the 50–79 year-old group. Major burdens were focused in middle to high-middle SDI regions, especially in Southern Latin America (Uruguay, Argentina, and Chile). Over 32 years, the burden of occupational TCE exposure-associated KC has gradually increased, with projections indicating continued growth to 2050, particularly among males and individuals aged 50–79. Regions like high-middle SDI areas, North America, High-income North America, Southern Sub-Saharan Africa, saw the most significant increases. Correlation analyses indicated a positive association between ASDR and ASDAR with SDI, while EAPC showed a notable negative correlation with SDI. Decomposition analyses reveals three global population determinants that positively contributed to the increase in deaths, but negatively impacted DALYs.</div></div><div><h3>Conclusion</h3><div>This study highlights a significant rising trend of occupational TCE exposure-associated KC from 1990 to 2021 and projected to 2050, with an emphasis on the disease burden in men, elderly population, and middle to high-middle SDI regions, underscoring the impact of occupational TCE exposure on KC.</div></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":"287 ","pages":"Article 117252"},"PeriodicalIF":6.2000,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ecotoxicology and Environmental Safety","FirstCategoryId":"93","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0147651324013289","RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Exposure to trichloroethylene (TCE) in occupations is associated with an increased risk of kidney cancer (KC). However, there is a lack of comprehensive study on the global burden of occupational exposure to TCE-related KC.

Methods

Epidemiological data on occupational TCE exposure-associated KC from 1990 to 2021 were obtained from Global Burden of Disease (GBD) 2021 study, including death counts and disability-adjusted life years (DALYs). Global burden of this disease was stratified by genders, age, socio-demographic index (SDI) quintiles, GBD subcontinental regions, and countries. The estimated annual percentage change (EAPC) was calculated to illustrate trends over the last 32 years, and forecasts were conducted to predict the disease burden until 2050.

Results

In 2021, the global age-standardized death rate (ASDR) of occupational TCE exposure-related KC was 0.0009 (95 %UI: 0.0002–0.0016) per 100,000 persons, and the age-standardized DALY rate (ASDAR) was 0.0284 (95 %UI: 0.0062–0.0522) per 100,000 individuals. The disease showed significant heterogeneity by sex and age, with males bearing a notably higher burden, and the burden being concentrated in the 50–79 year-old group. Major burdens were focused in middle to high-middle SDI regions, especially in Southern Latin America (Uruguay, Argentina, and Chile). Over 32 years, the burden of occupational TCE exposure-associated KC has gradually increased, with projections indicating continued growth to 2050, particularly among males and individuals aged 50–79. Regions like high-middle SDI areas, North America, High-income North America, Southern Sub-Saharan Africa, saw the most significant increases. Correlation analyses indicated a positive association between ASDR and ASDAR with SDI, while EAPC showed a notable negative correlation with SDI. Decomposition analyses reveals three global population determinants that positively contributed to the increase in deaths, but negatively impacted DALYs.

Conclusion

This study highlights a significant rising trend of occupational TCE exposure-associated KC from 1990 to 2021 and projected to 2050, with an emphasis on the disease burden in men, elderly population, and middle to high-middle SDI regions, underscoring the impact of occupational TCE exposure on KC.

查看原文本刊更多论文

职业性三氯乙烯（TCE）暴露相关肾癌的全球趋势和预测：2021年全球疾病负担（GBD）研究从1990年到2021年的洞察以及到2050年的预测。

背景：职业暴露于三氯乙烯（TCE）会增加罹患肾癌（KC）的风险。然而，目前还缺乏对全球职业接触三氯乙烯相关肾癌负担的全面研究：方法：从 2021 年全球疾病负担（GBD）研究中获得了 1990 年至 2021 年职业接触三氯乙烯相关肾癌的流行病学数据，包括死亡人数和残疾调整生命年（DALYs）。该疾病的全球负担按性别、年龄、社会人口指数（SDI）五分位数、GBD 次大陆地区和国家进行了分层。通过计算估计年百分比变化（EAPC）来说明过去 32 年的趋势，并对 2050 年之前的疾病负担进行预测：结果：2021 年，全球与职业三氯乙烷接触相关的 KC 年龄标准化死亡率（ASDR）为每 10 万人 0.0009（95 %UI：0.0002-0.0016），年龄标准化残疾调整寿命率（ASDAR）为每 10 万人 0.0284（95 %UI：0.0062-0.0522）。该疾病在性别和年龄上表现出明显的异质性，男性的负担明显较高，负担主要集中在 50-79 岁年龄组。主要负担集中在中高 SDI 地区，尤其是拉丁美洲南部（乌拉圭、阿根廷和智利）。32 年来，与职业性三氯乙烷暴露相关的 KC 负担逐渐增加，预计到 2050 年将继续增长，尤其是在男性和 50-79 岁的人群中。中高 SDI 地区、北美、北美高收入地区、撒哈拉以南非洲南部等地区的增长最为显著。相关分析表明，ASDR 和 ASDAR 与 SDI 呈正相关，而 EAPC 与 SDI 呈明显的负相关。分解分析表明，三个全球人口决定因素对死亡人数的增加有积极作用，但对残疾调整寿命年数有消极影响：本研究强调了从 1990 年到 2021 年以及预计到 2050 年与职业性三氯乙烷暴露相关的 KC 的显著上升趋势，重点是男性、老年人口和 SDI 中上水平地区的疾病负担，突出了职业性三氯乙烷暴露对 KC 的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Ecotoxicology and Environmental Safety 环境科学-毒理学

CiteScore

12.10

自引率

5.90%

发文量

1234

审稿时长

88 days

期刊介绍： Ecotoxicology and Environmental Safety is a multi-disciplinary journal that focuses on understanding the exposure and effects of environmental contamination on organisms including human health. The scope of the journal covers three main themes. The topics within these themes, indicated below, include (but are not limited to) the following: Ecotoxicology、Environmental Chemistry、Environmental Safety etc.