Crystal Transduction 3D Printing of Bio-Hydrogels with High Fidelity and Order Micro Pores

IF 5.1 Q1 POLYMER SCIENCE

ACS Macro Letters Pub Date : 2024-11-06 DOI:10.1002/adfm.202415799

Han Tian, Yanyu Hu, Jiajie Wu, Rixuan Wang, Jing Wang, Xixi Cai, Xu Chen, Yong He, Shaoyun Wang

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Abstract

3D printing of bio-hydrogel scaffolds are widely used in tissue regeneration. However, due to the ultra-soft properties of bio-hydrogels, it is hard to print them precisely. Here, crystal transduction 3D printing with high fidelity is proposed to address this challenge. A phase-transition bio-inks system with beeswax is developed for crystal transduction, which can accelerate energy consumption and induce soft bio-inks to quickly harden during printing. Interestingly, an interconnected porous hydrogel scaffold can be obtained after washing the crystal beeswax. The porous hydrogel scaffold demonstrated excellent biocompatibility and cell proliferation effect in vitro and is free from defense responses and immunogenicity in vivo. Muscle analog porous scaffolds constructed by high-fidelity 3D printing significantly improve the tissue function recovery of rats with muscle defects, compared with the conventional printed hydrogel with a non-matched shape. These structure-performance design rules create exciting opportunities to customize 3D-printed porous hydrogel scaffolds with high fidelity.

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晶体传导三维打印具有高保真和有序微孔的生物水凝胶

三维打印生物水凝胶支架广泛应用于组织再生。然而，由于生物水凝胶的超软特性，很难对其进行精确打印。为解决这一难题，我们提出了高保真晶体传导三维打印技术。为实现晶体传导，开发了一种含有蜂蜡的相变生物墨水系统，该系统可加快能量消耗，并促使柔软的生物墨水在打印过程中快速硬化。有趣的是，在清洗晶体蜂蜡后，可以得到一个相互连接的多孔水凝胶支架。这种多孔水凝胶支架在体外具有良好的生物相容性和细胞增殖效果，在体内无防御反应和免疫原性。与形状不匹配的传统打印水凝胶相比，通过高保真三维打印技术构建的肌肉模拟多孔支架能显著改善肌肉缺损大鼠的组织功能恢复。这些结构-性能设计规则为高保真定制三维打印多孔水凝胶支架创造了令人兴奋的机会。

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来源期刊

ACS Macro Letters 化学-

CiteScore

10.40

自引率

3.40%

发文量

209

审稿时长

1 months

期刊介绍： ACS Macro Letters publishes research in all areas of contemporary soft matter science in which macromolecules play a key role, including nanotechnology, self-assembly, supramolecular chemistry, biomaterials, energy generation and storage, and renewable/sustainable materials. Submissions to ACS Macro Letters should justify clearly the rapid disclosure of the key elements of the study. The scope of the journal includes high-impact research of broad interest in all areas of polymer science and engineering, including cross-disciplinary research that interfaces with polymer science. With the launch of ACS Macro Letters, all Communications that were formerly published in Macromolecules and Biomacromolecules will be published as Letters in ACS Macro Letters.