Ocular drug delivery strategies using carbon nanotubes: A perspective

IF 2.7 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials Letters Pub Date : 2024-11-01 DOI:10.1016/j.matlet.2024.137642

Lidiya Sonowal, Sanjeev Gautam

引用次数: 0

Abstract

Ocular drug delivery has its own set of challenges due to the eye’s complexity and barriers. Various nanocarriers have been developed to deliver drugs to the eye; however, this work focuses on carbon nanotubes (CNTs) as a nanocarrier. CNTs have unique properties that can address the challenges associated with ocular drug delivery. The novelty of this work is to integrate CNTs with ocular drugs to improve solubility, transport across barriers and sustained release. The structure and properties of CNTs are discussed in the context of ophthalmic applications. Functionalization of CNTs to enhance biocompatibility and optimize drug delivery is also discussed with recent updates. The key applications include improving solubility, penetration through ocular barriers and controlled release. Future directions and emerging trends in nanotechnology for ocular drug delivery are also considered herein.

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使用碳纳米管的眼部给药策略：透视

由于眼睛的复杂性和障碍性，眼部给药面临着一系列挑战。目前已开发出多种纳米载体，用于向眼部递送药物；不过，这项工作的重点是将碳纳米管（CNTs）作为纳米载体。碳纳米管具有独特的性质，可以应对眼部给药的相关挑战。这项工作的新颖之处在于将碳纳米管与眼部药物相结合，以提高药物的溶解度、跨障碍传输和持续释放。本文结合眼科应用讨论了碳纳米管的结构和特性。此外，还讨论了为增强生物相容性和优化药物输送而对碳纳米管进行功能化的最新进展。主要应用包括提高溶解度、穿透眼屏障和控制释放。本文还探讨了眼部给药纳米技术的未来发展方向和新兴趋势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Materials Letters 工程技术-材料科学：综合

CiteScore

5.60

自引率

3.30%

发文量

1948

审稿时长

50 days

期刊介绍： Materials Letters has an open access mirror journal Materials Letters: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Materials Letters is dedicated to publishing novel, cutting edge reports of broad interest to the materials community. The journal provides a forum for materials scientists and engineers, physicists, and chemists to rapidly communicate on the most important topics in the field of materials. Contributions include, but are not limited to, a variety of topics such as: • Materials - Metals and alloys, amorphous solids, ceramics, composites, polymers, semiconductors • Applications - Structural, opto-electronic, magnetic, medical, MEMS, sensors, smart • Characterization - Analytical, microscopy, scanning probes, nanoscopic, optical, electrical, magnetic, acoustic, spectroscopic, diffraction • Novel Materials - Micro and nanostructures (nanowires, nanotubes, nanoparticles), nanocomposites, thin films, superlattices, quantum dots. • Processing - Crystal growth, thin film processing, sol-gel processing, mechanical processing, assembly, nanocrystalline processing. • Properties - Mechanical, magnetic, optical, electrical, ferroelectric, thermal, interfacial, transport, thermodynamic • Synthesis - Quenching, solid state, solidification, solution synthesis, vapor deposition, high pressure, explosive