Highly oxidized sesquiterpenoids from Parasenecio rubescens and assessment of their cytotoxicity

IF 4 2区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE
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引用次数: 0

Abstract

A phytochemical investigation of the whole plant of Parasenecio rubescens (S. Moore) Y. L. Chen yielded 14 previously undescribed, highly oxidized bisabolane-type sesquiterpenoids, named pararunines L–Y, along with one known oplopane-type sesquiterpenoid. The structural elucidation of these compounds was accomplished through comprehensive spectroscopic analysis, including nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) techniques. Motivated by traditional uses and previous studies on this genus, all isolated compounds were subjected to in vitro cytotoxicity assays against four human cancer cell lines (MCF-7, Hela, HCT116, and HT-29). Considering that the reported chemical constituents of numerous other species within this genus primarily consist of eremophilane-type sesquiterpenoids, our findings not only expand the structural diversity of bisabolane-type sesquiterpenoids but also contribute valuable scientific evidence to the chemotaxonomy of this genus.
来自 Parasenecio rubescens 的高氧化倍半萜类化合物及其细胞毒性评估
通过对 Parasenecio rubescens (S. Moore) Y. L. Chen 的全草进行植物化学研究,发现了 14 种以前未曾描述过的、高度氧化的双苯甲酸酯类倍半萜化合物,命名为 Pararunines L-Y,以及一种已知的 oplopane 类倍半萜化合物。通过全面的光谱分析,包括核磁共振(NMR)和高分辨率电喷雾质谱(HR-ESI-MS)技术,对这些化合物的结构进行了阐明。受该属植物的传统用途和先前研究的启发,对所有分离出的化合物进行了体外细胞毒性试验,以检测其对四种人类癌细胞系(MCF-7、Hela、HCT116 和 HT-29)的毒性。考虑到已报道的该属中许多其他物种的化学成分主要由酯类倍半萜类化合物组成,我们的研究结果不仅扩大了双香蒲烷类倍半萜类化合物的结构多样性,还为该属的化学分类学提供了宝贵的科学证据。
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来源期刊
Chinese Journal of Natural Medicines
Chinese Journal of Natural Medicines INTEGRATIVE & COMPLEMENTARY MEDICINE-PHARMACOLOGY & PHARMACY
CiteScore
7.50
自引率
4.30%
发文量
2235
期刊介绍: The Chinese Journal of Natural Medicines (CJNM), founded and sponsored in May 2003 by China Pharmaceutical University and the Chinese Pharmaceutical Association, is devoted to communication among pharmaceutical and medical scientists interested in the advancement of Traditional Chinese Medicines (TCM). CJNM publishes articles relating to a broad spectrum of bioactive natural products, leading compounds and medicines derived from Traditional Chinese Medicines (TCM). Topics covered by the journal are: Resources of Traditional Chinese Medicines; Interaction and complexity of prescription; Natural Products Chemistry (including structure modification, semi-and total synthesis, bio-transformation); Pharmacology of natural products and prescription (including pharmacokinetics and toxicology); Pharmaceutics and Analytical Methods of natural products.
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