NO inhibitory constituents from Glycosmis craibii var. glabra

IF 4 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Chinese Journal of Natural Medicines Pub Date : 2024-11-01 DOI:10.1016/S1875-5364(24)60632-1

Hongwei CHEN , Meng DING , Jun LIN , Shuo YUAN , Kewu ZENG , Pengfei TU , Yong JIANG

引用次数: 0

Abstract

Six novel compounds, comprising three quinolones (1a, 1b, and 2) and three flavanones (3–5), along with seven known analogs (6–13), were isolated from the 95% EtOH extract of the stems and leaves of Glycosmis craibii var. glabra. The structures of the new compounds were elucidated using HR-ESI-MS, UV, and 1D and 2D nuclear magnetic resonance (NMR) data analysis. The absolute configurations were determined through Mosher ester and electronic circular dichroism (ECD) spectral analysis. Compounds 2, 6, 9, and 10 demonstrated inhibition of nitric oxide (NO) production stimulated by lipopolysaccharide in BV-2 microglial cells, with IC₅₀ values ranging from 13.5 to 20.1 μmol·L⁻¹, comparable to the positive control, dexamethasone.

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Glycosmis craibii var. glabra 中的氮氧化物抑制成分

从 Glycosmis craibii var. glabra 的茎和叶的 95% EtOH 提取物中分离出六种新化合物，包括三种喹诺酮类（1a、1b 和 2）和三种黄酮类（3-5），以及七种已知类似物（6-13）。利用 HR-ESI-MS、紫外光谱以及一维和二维核磁共振（NMR）数据分析阐明了这些新化合物的结构。通过莫舍酯和电子圆二色性（ECD）光谱分析确定了绝对构型。化合物 2、6、9 和 10 能抑制 BV-2 微神经胶质细胞在脂多糖刺激下产生一氧化氮，其 IC50 值为 13.5 至 20.1 μmol-L-1，与阳性对照地塞米松相当。

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来源期刊

Chinese Journal of Natural Medicines INTEGRATIVE & COMPLEMENTARY MEDICINE-PHARMACOLOGY & PHARMACY

CiteScore

7.50

自引率

4.30%

发文量

2235

期刊介绍： The Chinese Journal of Natural Medicines (CJNM), founded and sponsored in May 2003 by China Pharmaceutical University and the Chinese Pharmaceutical Association, is devoted to communication among pharmaceutical and medical scientists interested in the advancement of Traditional Chinese Medicines (TCM). CJNM publishes articles relating to a broad spectrum of bioactive natural products, leading compounds and medicines derived from Traditional Chinese Medicines (TCM). Topics covered by the journal are: Resources of Traditional Chinese Medicines; Interaction and complexity of prescription; Natural Products Chemistry (including structure modification, semi-and total synthesis, bio-transformation); Pharmacology of natural products and prescription (including pharmacokinetics and toxicology); Pharmaceutics and Analytical Methods of natural products.