Exploring the Peaks and Potholes: Understanding positive and negative effects of concentrated exposure treatment for obsessive-compulsive disorder

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-10-01 DOI:10.1016/j.jocrd.2024.100913

Lena Jelinek , Anna Serve , Saskia Pampuch , Jakob Scheunemann , Josephine Schultz , Franziska Miegel , Bjarne Hansen , Kristen Hagen , Frances Bohnsack , Jürgen Gallinat , Amir H. Yassari

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引用次数: 0

Abstract

The Bergen 4-Day Treatment offers brief concentrated exposure with response prevention (cERP) for obsessive-compulsive disorder (OCD). To date, this intervention has primarily been studied in Norway, and no study has been done on its side effects. We tested the safety, feasibility, and effectiveness of cERP in Germany and compared cERP to a historical inpatient control group.

Thirty-three patients with OCD were treated with cERP. We assessed severity of OCD (primary outcome: Y-BOCS), depression, global functioning, self-esteem, self-efficacy, experiential avoidance, and quality of life at baseline (t0), two weeks after t0 (t1), and three months after t1 (t2). Side effects were assessed at t1 and t2. The changes in OCD were compared to a matched historical inpatient control group (n = 33) treated at the same site.

The cERP group improved over time, with a large effect size in OCD symptoms and other outcome measures. Improvement of OCD symptoms over treatment was superior in the cERP group compared to the historical control group, with a medium effect size for OCD symptoms. 53–56% of the participants reported at least one side effect (e.g., exhaustion). cERP is safe and effective in the treatment of OCD and can be successfully implemented in Germany.

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探索高峰与低谷：了解集中暴露疗法对强迫症的积极和消极影响

卑尔根四日疗法为强迫症（OCD）提供简短的集中暴露和反应预防（cERP）。迄今为止，这项干预措施主要是在挪威进行的研究，尚未对其副作用进行研究。我们在德国测试了 cERP 的安全性、可行性和有效性，并将 cERP 与历史住院对照组进行了比较。我们在基线（t0）、t0 后两周（t1）和 t1 后三个月（t2）评估了强迫症的严重程度（主要结果：Y-BOCS）、抑郁、整体功能、自尊、自我效能、经验回避和生活质量。副作用在治疗第一阶段和第二阶段进行评估。强迫症的变化情况与在同一地点接受治疗的匹配历史住院病人对照组（n = 33）进行了比较。与历史对照组相比，cERP 组的强迫症症状在治疗过程中的改善程度更好，强迫症症状的影响程度为中等。53%-56%的参与者报告了至少一种副作用（如疲惫）。cERP治疗强迫症安全有效，可在德国成功实施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.