Local antimicrobial delivery systems for prophylaxis and treatment of periprosthetic traumatological infections

IF 4.3 3区医学 Q1 PHARMACOLOGY & PHARMACY

European Journal of Pharmaceutical Sciences Pub Date : 2024-11-05 DOI:10.1016/j.ejps.2024.106940

Juan Aparicio-Blanco , Irene I. López-Torres , María Alonso-Berenguel , Ana I. Torres-Suárez , Cristina Martín-Sabroso

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引用次数: 0

Abstract

Infections associated with implants are the most serious complications in joint replacement surgeries and can jeopardize the functionality of orthopedic implants. Local antimicrobial delivery could enable antibiotics to attain concentrations above the minimum inhibitory concentration (MIC) threshold at the joint replacement site while preventing systemic side effects.

Therefore, there is a dire need for the development of improved biomaterial-based delivery systems for local antibiotic administration in prosthetic infections. In this context, this review highlights the latest breakthroughs in the design of biomaterial-based formulations intended for the prophylaxis and treatment of prosthetic infections. Delivery systems for distinct forms of administration (i.e., direct intra-articular administration, loading into bone cements, coating of implant surfaces, or loading into hydrogels) are here comprehensively compiled with a focus on the design of microparticles and nanosystems for local antimicrobial administration and their impact on distinct in vitro and in vivo models of implant infections.

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用于预防和治疗假体周围创伤感染的局部抗菌给药系统

与植入物相关的感染是关节置换手术中最严重的并发症，会危及骨科植入物的功能。局部抗菌给药可使抗生素在关节置换部位达到高于最小抑菌浓度（MIC）阈值的浓度，同时防止全身副作用。因此，亟需开发改进的基于生物材料的给药系统，用于假体感染的局部抗生素给药。在此背景下，本综述重点介绍了用于预防和治疗假体感染的生物材料制剂设计方面的最新突破。本综述全面汇集了不同给药形式的给药系统（即关节内直接给药、装入骨水泥、包覆植入物表面或装入水凝胶），重点介绍了用于局部抗菌给药的微粒和纳米系统的设计及其对不同的植入物感染体外和体内模型的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Pharmaceutical Sciences 医学-药学

CiteScore

9.60

自引率

2.20%

发文量

248

审稿时长

50 days

期刊介绍： The journal publishes research articles, review articles and scientific commentaries on all aspects of the pharmaceutical sciences with emphasis on conceptual novelty and scientific quality. The Editors welcome articles in this multidisciplinary field, with a focus on topics relevant for drug discovery and development. More specifically, the Journal publishes reports on medicinal chemistry, pharmacology, drug absorption and metabolism, pharmacokinetics and pharmacodynamics, pharmaceutical and biomedical analysis, drug delivery (including gene delivery), drug targeting, pharmaceutical technology, pharmaceutical biotechnology and clinical drug evaluation. The journal will typically not give priority to manuscripts focusing primarily on organic synthesis, natural products, adaptation of analytical approaches, or discussions pertaining to drug policy making. Scientific commentaries and review articles are generally by invitation only or by consent of the Editors. Proceedings of scientific meetings may be published as special issues or supplements to the Journal.