Association of PIRCHE-II score with anti-donor T-cell response and risk of de novo donor-specific antibody production in kidney transplant recipients

IF 1.6 4区医学 Q4 IMMUNOLOGY

Transplant immunology Pub Date : 2024-11-03 DOI:10.1016/j.trim.2024.102145

Hiroaki Yamane, Kentaro Ide, Yuka Tanaka, Masahiro Ohira, Hiroyuki Tahara, Seiichi Shimizu, Hiroshi Sakai, Ryosuke Nakano, Hideki Ohdan

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引用次数: 0

Abstract

Background

De novo donor-specific antibodies (dnDSAs) affect long-term outcomes of kidney transplantation (KT). A higher Predicted Indirectly ReCognizable Human Leukocyte Antigen (HLA) Epitopes (PIRCHE-II) score correlates with various clinical outcomes, including dnDSA formation. However, a detailed analysis of the relationship between the PIRCHE-II score and anti-donor T-cell response is lacking. Therefore, this study investigated the relationship between PIRCHE-II scores associated with dnDSA formation and mixed lymphocyte reaction results of anti-donor T-cell response.

Methods

Data of 105 adult living-donor KT recipients were retrospectively assessed.

Results

Of the 105 patients, 13.3 % developed dnDSAs during the observation period. The PIRCHE-II score at the HLA-DQ locus (PIRCHE-DQ) was significantly higher in patients with dnDSA formation than in those without. The incidence of dnDSA formation was significantly higher in the PIRCHE-DQ ≥ 77 group than in the PIRCHE-DQ < 77 group. The proportion of patients with increased anti-donor T-cell response was significantly higher in the PIRCHE-DQ ≥ 77 group than in the PIRCHE-DQ < 77 group before KT and at 4 and 5 years after KT.

Conclusions

PIRCHE-DQ may predict dnDSA formation and anti-donor T-cell response. Reducing the immunosuppressive drug dose in cases of high PIRCHE-DQ might not be prudent.

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肾移植受者的 PIRCHE-II 评分与抗供体 T 细胞反应和新的供体特异性抗体产生风险的关系。

背景：新的供体特异性抗体（dnDSAs）会影响肾移植（KT）的长期预后。较高的预测间接再识别人类白细胞抗原（HLA）表位（PIRCHE-II）得分与各种临床结果相关，包括dnDSA的形成。然而，目前还缺乏对 PIRCHE-II 评分与抗供体 T 细胞反应之间关系的详细分析。因此，本研究调查了与 dnDSA 形成相关的 PIRCHE-II 评分与抗供体 T 细胞反应的混合淋巴细胞反应结果之间的关系：方法：回顾性评估了105例成年活体KT受者的数据：结果：在105名患者中，13.3%在观察期间出现了dnDSAs。HLA-DQ 位点的 PIRCHE-II 评分（PIRCHE-DQ）在形成 dnDSA 的患者中明显高于未形成 dnDSA 的患者。PIRCHE-DQ≥77 组的 dnDSA 形成率明显高于 PIRCHE-DQ 结论：PIRCHE-DQ可预测dnDSA的形成和抗供体T细胞反应。在 PIRCHE-DQ 偏高的情况下，减少免疫抑制药物的剂量可能并非明智之举。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Transplant immunology 医学-免疫学

CiteScore

2.10

自引率

13.30%

发文量

198

审稿时长

48 days

期刊介绍： Transplant Immunology will publish up-to-date information on all aspects of the broad field it encompasses. The journal will be directed at (basic) scientists, tissue typers, transplant physicians and surgeons, and research and data on all immunological aspects of organ-, tissue- and (haematopoietic) stem cell transplantation are of potential interest to the readers of Transplant Immunology. Original papers, Review articles and Hypotheses will be considered for publication and submitted manuscripts will be rapidly peer-reviewed and published. They will be judged on the basis of scientific merit, originality, timeliness and quality.