Determinants of antiretroviral therapy adherence among people living with HIV in a poor urban setting in Ghana: a hospital-based cross-sectional study.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-11-06 DOI:10.1093/trstmh/trae091

Evelyn Adjei-Mensah, Yakubu Alhassan, Richmond Owusu, Irene A Kretchy

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Abstract

Background: Without a cure, antiretroviral therapy (ART) continues to be the primary mode of managing HIV, transforming it from a formerly lethal disease to a less severe one. Adherence to ART can be impacted by several factors, including poor quality of care.

Methods: A quantitative cross-sectional study design was used to assess the factors that influence adherence to ART among adults receiving care at two health facilities in Accra. A structured interviewer-administered questionnaire was used to collect data on factors associated with medication adherence using a modified four-item Medication Adherence Rating from 255 people living with HIV (PLHIV). Descriptive statistics were used to summarise the data, while multiple binary logistic regression was used to assess the factors influencing adherence to ART.

Results: Adherence to HIV medication was 44.7% among PLHIV. Adherence was positively correlated with high client health service satisfaction (adjusted OR [AOR]: 26.59, 95% CI 7.46 to 94.82, p<0.001), increased privacy at the HIV clinics (AOR: 3.40, 95% CI 1.40 to 8.21, p<0.007) and among PLHIV who had been diagnosed with HIV for ≥5 y (AOR: 7.59, 95% CI 2.76 to 20.85, p<0.001).

Conclusions: Adherence to ART was significantly low among study participants. The study highlights the importance of maintaining privacy and confidentiality at the facility while ensuring client satisfaction with HIV care to promote adherence to ART.

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加纳城市贫困地区艾滋病病毒感染者坚持抗逆转录病毒治疗的决定因素：一项基于医院的横断面研究。

背景：在无法治愈的情况下，抗逆转录病毒疗法（ART）仍然是治疗艾滋病的主要方式，它使艾滋病从过去的致命疾病转变为不太严重的疾病。坚持抗逆转录病毒疗法会受到多种因素的影响，包括护理质量低下：方法：采用定量横断面研究设计，评估影响在阿克拉两家医疗机构接受治疗的成年人坚持抗逆转录病毒疗法的因素。研究采用结构化访谈问卷的形式，通过修改后的四项用药依从性评分，收集了255名艾滋病病毒感染者（PLHIV）的用药依从性相关因素的数据。描述性统计用于总结数据，而多元二元逻辑回归则用于评估影响坚持抗逆转录病毒疗法的因素：结果：PLHIV 中坚持接受艾滋病药物治疗的比例为 44.7%。坚持治疗与客户对医疗服务的高满意度呈正相关（调整后 OR [AOR]：26.59，95% CI 7.46 至 94.82，pConclusions）：研究参与者的抗逆转录病毒疗法依从性明显偏低。这项研究强调了在确保客户对艾滋病护理满意度的同时，维护医疗机构的隐私和保密性对促进坚持抗逆转录病毒疗法的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.