Effects of probiotics on selected anthropometrics and biochemical measures in overweight or obese Saudi subjects: a double-blind, placebo-controlled, randomised clinical trial.

IF 3 3区 医学 Q2 NUTRITION & DIETETICS
Samira M AlMalki, Hanan A Alfawaz, Turki A Binmoammar, Saleh F AlBahlei, Luluah M Al Bakr, Ahmed M Alzahrani, Salem S Alshammari, Syed Danish Hussain, Shaun Sabico, Nasser M Al-Daghri
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Abstract

Objective: This study aimed to assess the effects of multi-strain probiotics on anthropometric and biochemical measures in Saudi adults with overweight or obesity.

Design: Single-centre, double-blind, placebo-controlled, randomised clinical trial.

Setting: Occupational Health Clinics at King Saud University Medical City, Riyadh, Saudi Arabia.

Participants: Ninety-three Saudi participants with overweight or obesity were randomly assigned to receive twice-daily doses of either placebo (n 49) or 30 × 109 CFU/g of HEXBIO® containing three Lactobacillus and three Bifidobacterium species (n 44) in a double-blind manner over a 12-week period, respectively. Both groups adhered to a hypoenergetic diet. Anthropometric measurements, glycaemic indices and lipid profiles were evaluated at baseline and post-intervention.

Results: Following the 12-week intervention, no statistically significant differences were found in all between the probiotic group and placebo group comparisons, except for fat intake, where the group*time interaction showed a significant decrease in favour of the probiotic group (P = 0·02). However, significant within-group reductions were observed in the probiotic group: body weight (-0·9 kg, P = 0·02), HC (-1·5 cm, P = 0·002), energy intake (-387·3 kcal/d, P = 0·002), fasting glucose (-0·7, P = 0·002) and LDL-cholesterol (-0·7, P = 0·02).

Conclusion: Consumption of multi-strain probiotic supplementation over 12 weeks significantly decreased fat intake in Saudi adults with overweight or obesity, with the probiotic group highlighting improved anthropometric and biochemical parameters. Further research is needed to evaluate the long-term clinical significance of this dietary practice and whether it has a meaningful impact on overall health beyond the placebo effect.

益生菌对超重或肥胖的沙特人特定人体测量指标和生化指标的影响:双盲、安慰剂对照随机临床试验。
研究目的本研究旨在评估多菌株益生菌对患有超重或肥胖症的沙特成年人的人体测量和生化指标的影响:单中心、双盲、安慰剂对照、随机临床试验:地点:沙特阿拉伯利雅得沙特国王大学医疗城职业健康诊所:93名患有超重或肥胖症的沙特参试者被随机分配到每天服用两次安慰剂(49人)或含有三种乳酸杆菌和三种双歧杆菌的30 × 109 CFU/g的HEXBIO®(44人),分别进行为期12周的双盲试验。两组均坚持低能量饮食。对基线和干预后的人体测量、血糖指数和血脂概况进行了评估:经过 12 周的干预后,益生菌组与安慰剂组之间的比较均未发现有统计学意义的显著差异,但脂肪摄入量除外,组与时间的交互作用显示,益生菌组的脂肪摄入量显著减少(P = 0-02)。然而,益生菌组在以下方面出现了明显的组内降低:体重(-0-9 千克,P = 0-02)、HC(-1-5 厘米,P = 0-002)、能量摄入(-387-3 千卡/天,P = 0-002)、空腹血糖(-0-7,P = 0-002)和低密度脂蛋白胆固醇(-0-7,P = 0-02):结论:多菌种益生菌补充剂在 12 周内可显著减少超重或肥胖的沙特成年人的脂肪摄入量,益生菌组的人体测量和生化指标均有所改善。还需要进一步的研究来评估这种饮食习惯的长期临床意义,以及除了安慰剂效应外,它是否会对整体健康产生有意义的影响。
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来源期刊
Public Health Nutrition
Public Health Nutrition 医学-公共卫生、环境卫生与职业卫生
CiteScore
6.10
自引率
6.20%
发文量
521
审稿时长
3 months
期刊介绍: Public Health Nutrition provides an international peer-reviewed forum for the publication and dissemination of research and scholarship aimed at understanding the causes of, and approaches and solutions to nutrition-related public health achievements, situations and problems around the world. The journal publishes original and commissioned articles, commentaries and discussion papers for debate. The journal is of interest to epidemiologists and health promotion specialists interested in the role of nutrition in disease prevention; academics and those involved in fieldwork and the application of research to identify practical solutions to important public health problems.
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